| Reaction Details |
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 | Report a problem with these data |
| Target | ATP-sensitive inward rectifier potassium channel 1 |
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| Ligand | BDBM194983 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Thallium Flux Assay |
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| Temperature | 310.15±n/a K |
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| IC50 | 40±n/a nM |
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| Comments | extracted |
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| Citation |  Ding, F; Dong, S; Frie, J; Gu, X; Jiang, J; Pasternak, A; Tang, H; Wu, Z; Yu, Y; Suzuki, T Inhibitors of the renal outer medullary potassium channel US Patent US9206198 Publication Date 12/8/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| ATP-sensitive inward rectifier potassium channel 1 |
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| Name: | ATP-sensitive inward rectifier potassium channel 1 |
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| Synonyms: | ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44809.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_223460826 |
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| Residue: | 391 |
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| Sequence: | MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQS
RFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTP
CVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILA
KISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGE
TIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGT
VESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLY
NEKDVRARMKRGYDNPNFILSEVNETDDTKM
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| BDBM194983 |
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| n/a |
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| Name | BDBM194983 |
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| Synonyms: | US9206198, 44 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H24N2O6 |
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| Mol. Mass. | 424.4465 |
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| SMILES | Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CC1)C=CN(C1=CC(=O)OC1)C2=O |r,c:23,t:26| |
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| Structure | 
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