Reaction Details | |||
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Target | Mitogen-activated protein kinase 1 | ||
Ligand | BDBM204294 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ERK2 (20 pM) Kinase Assay | ||
pH | 7.5±n/a | ||
IC50 | 0.00837±n/a nM | ||
Comments | extracted | ||
Citation | Bagdanoff, JT; Ding, Y; Han, W; Huang, Z; Jiang, Q; Jin, JX; Kou, X; Lee, P; Lindvall, M; Min, Z; Pan, Y; Pecchi, S; Pfister, KB; Poon, D; Rauniyar, V; Wang, XM; Zhang, Q; Zhou, J; Zhu, S Aminoheteroaryl benzamides as kinase inhibitors US Patent US9242996 Publication Date 1/26/2016 | ||
More Info.: | Get all data from this article, Assay Method | ||
Mitogen-activated protein kinase 1 | |||
Name: | Mitogen-activated protein kinase 1 | ||
Synonyms: | ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK | ||
Type: | Ser/Thr Protein Kinase | ||
Mol. Mass.: | 41392.76 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P28482 | ||
Residue: | 360 | ||
Sequence: |
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BDBM204294 | |||
n/a | |||
Name | BDBM204294 | ||
Synonyms: | US9242996, 373 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H26F2IN5O2 | ||
Mol. Mass. | 593.4075 | ||
SMILES | NC[C@@H](NC(=O)c1ccc(cc1F)-c1nc(cnc1N)[C@H]1CC[C@H](O)CC1)c1cc(F)cc(I)c1 |r,wU:23.25,wD:20.21,2.2,(4,6.93,;2.67,6.16,;2.67,4.62,;1.33,3.85,;,4.62,;,6.16,;-1.33,3.85,;-1.33,2.31,;-2.67,1.54,;-4,2.31,;-4,3.85,;-2.67,4.62,;-2.67,6.16,;-5.33,1.54,;-5.33,,;-6.67,-.77,;-8,,;-8,1.54,;-6.67,2.31,;-6.67,3.85,;-6.67,-2.31,;-8,-3.08,;-8,-4.62,;-6.67,-5.39,;-6.67,-6.93,;-5.33,-4.62,;-5.33,-3.08,;4,3.85,;5.33,4.62,;6.67,3.85,;8,4.62,;6.67,2.31,;5.33,1.54,;5.33,,;4,2.31,)| | ||
Structure |