Ki Summary

Reaction Details

Report a problem with these data

Target

Mitogen-activated protein kinase 1

Ligand

BDBM204295

Substrate/Competitor

n/a

Meas. Tech.

ERK2 (20 pM) Kinase Assay

7.5±n/a

IC50

0.0205±n/a nM

Comments

extracted

Citation

Bagdanoff, JT; Ding, Y; Han, W; Huang, Z; Jiang, Q; Jin, JX; Kou, X; Lee, P; Lindvall, M; Min, Z; Pan, Y; Pecchi, S; Pfister, KB; Poon, D; Rauniyar, V; Wang, XM; Zhang, Q; Zhou, J; Zhu, S Aminoheteroaryl benzamides as kinase inhibitors US Patent US9242996 Publication Date 1/26/2016

More Info.:

Get all data from this article, Assay Method

Mitogen-activated protein kinase 1

Name:

Mitogen-activated protein kinase 1

Synonyms:

Type:

Ser/Thr Protein Kinase

Mol. Mass.:

41392.76

Organism:

Homo sapiens (Human)

Description:

P28482

Residue:

360

Sequence:

MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS

BDBM204295

n/a

Name

BDBM204295

Synonyms:

US9242996, 374

Type

Small organic molecule

Emp. Form.

C27H30BrF2N5O2

Mol. Mass.

574.46

SMILES

CNC[C@@H](NC(=O)c1ccc(cc1F)-c1nc(cnc1N)[C@H]1CC[C@@H](CC1)OC)c1cc(F)cc(Br)c1 |r,wU:21.22,wD:3.3,24.29,(5.33,6.54,;4,7.31,;2.67,6.54,;2.67,5,;1.33,4.23,;,5,;,6.54,;-1.33,4.23,;-1.33,2.69,;-2.67,1.92,;-4,2.69,;-4,4.23,;-2.67,5,;-2.67,6.54,;-5.33,1.92,;-5.33,.38,;-6.67,-.39,;-8,.38,;-8,1.92,;-6.67,2.69,;-6.67,4.23,;-6.67,-1.93,;-5.33,-2.7,;-5.33,-4.24,;-6.67,-5.01,;-8,-4.24,;-8,-2.7,;-6.67,-6.54,;-5.33,-7.31,;4,4.23,;5.33,5,;6.67,4.23,;8,5,;6.67,2.69,;5.33,1.92,;5.33,.39,;4,2.69,)|

Structure