Ki Summary

Reaction Details

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Target

Mitogen-activated protein kinase 1

Ligand

BDBM204303

Substrate/Competitor

n/a

Meas. Tech.

ERK2 (20 pM) Kinase Assay

7.5±n/a

IC50

0.0107±n/a nM

Comments

extracted

Citation

Bagdanoff, JT; Ding, Y; Han, W; Huang, Z; Jiang, Q; Jin, JX; Kou, X; Lee, P; Lindvall, M; Min, Z; Pan, Y; Pecchi, S; Pfister, KB; Poon, D; Rauniyar, V; Wang, XM; Zhang, Q; Zhou, J; Zhu, S Aminoheteroaryl benzamides as kinase inhibitors US Patent US9242996 Publication Date 1/26/2016

More Info.:

Get all data from this article, Assay Method

Mitogen-activated protein kinase 1

Name:

Mitogen-activated protein kinase 1

Synonyms:

Type:

Ser/Thr Protein Kinase

Mol. Mass.:

41392.76

Organism:

Homo sapiens (Human)

Description:

P28482

Residue:

360

Sequence:

MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS

BDBM204303

n/a

Name

BDBM204303

Synonyms:

US9242996, 382

Type

Small organic molecule

Emp. Form.

C26H28F2IN5O2

Mol. Mass.

607.4341

SMILES

CO[C@H]1CC[C@@H](CC1)c1cnc(N)c(n1)-c1ccc(C(=O)N[C@H](CN)c2cc(F)cc(I)c2)c(F)c1 |r,wU:2.1,wD:5.8,22.23,(-5.33,-7.31,;-6.67,-6.54,;-6.67,-5.01,;-8,-4.24,;-8,-2.7,;-6.67,-1.93,;-5.33,-2.7,;-5.33,-4.24,;-6.67,-.39,;-8,.38,;-8,1.92,;-6.67,2.69,;-6.67,4.23,;-5.33,1.92,;-5.33,.38,;-4,2.69,;-2.67,1.92,;-1.33,2.69,;-1.33,4.23,;,5,;,6.54,;1.33,4.23,;2.67,5,;2.67,6.54,;4,7.31,;4,4.23,;5.33,5,;6.67,4.23,;8,5,;6.67,2.69,;5.33,1.92,;5.33,.39,;4,2.69,;-2.67,5,;-2.67,6.54,;-4,4.23,)|

Structure