Reaction Details |
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Target | Glycogen synthase kinase-3 alpha |
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Ligand | BDBM142598 |
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Substrate/Competitor | n/a |
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Meas. Tech. | GSK 3α Enzyme Inhibition Assay |
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IC50 | 45±n/a nM |
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Citation | Duffy, LA; King-Underwood, J; Longshaw, AI; Murray, PJ; Onions, ST; Taddei, DM; Williams, JG; Ito, K; Charron, CE Pyrazole derivatives as p38 MAP inhibitors US Patent US9249125 Publication Date 2/2/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Glycogen synthase kinase-3 alpha |
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Name: | Glycogen synthase kinase-3 alpha |
Synonyms: | GSK-3 alpha | GSK3A | GSK3A_HUMAN | Glycogen synthase kinase 3 alpha (GSKalpha) | Glycogen synthase kinase-3 | Glycogen synthase kinase-3 alpha | Glycogen synthase kinase-3 alpha (GSK3 Alpha) | Glycogen synthase kinase-3 alpha (GSK3A) | Glycogen synthase kinase-3 alpha (GSK3alpha) |
Type: | Enzyme |
Mol. Mass.: | 50991.79 |
Organism: | Homo sapiens (Human) |
Description: | P49840 |
Residue: | 483 |
Sequence: | MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGV
GASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYT
DIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFY
SSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGV
CHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSS
IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIK
AHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLP
PLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLT
NSS
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BDBM142598 |
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n/a |
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Name | BDBM142598 |
Synonyms: | US10238658, Example Reference | US10813932, Reference Compound | US8933228, Ref 2 | US9242960, 1 | US9249125, Reference Compound | US9701670, Reference Compound | US9724347, Example Reference | US9993478, Example Reference |
Type | Small organic molecule |
Emp. Form. | C33H34N6O4 |
Mol. Mass. | 578.6609 |
SMILES | COCC(=O)Nc1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1 |
Structure |
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