| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PAK 1 [249-545,K299R] |
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| Ligand | BDBM50112347 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Z'-LYTEBiochemical Assay |
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| IC50 | 7.7±0.0 nM |
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| Citation |  Licciulli, S; Maksimoska, J; Zhou, C; Troutman, S; Kota, S; Liu, Q; Duron, S; Campbell, D; Chernoff, J; Field, J; Marmorstein, R; Kissil, JL FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas. J Biol Chem288:29105-14 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase PAK 1 [249-545,K299R] |
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| Name: | Serine/threonine-protein kinase PAK 1 [249-545,K299R] |
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| Synonyms: | PAK1 | PAK1_HUMAN | p21-Activated kinase 1 (PAK1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 33244.90 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human PAK1 truncation (249-545 aa) with K299R mutation |
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| Residue: | 297 |
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| Sequence: | SDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPK
KELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAA
VCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTP
YWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPE
KLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATKNNH
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| BDBM50112347 |
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| n/a |
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| Name | BDBM50112347 |
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| Synonyms: | CHEMBL3609327 | FRAX597 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H28ClN7OS |
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| Mol. Mass. | 558.097 |
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| SMILES | CCn1c2nc(Nc3ccc(cc3)N3CCN(C)CC3)ncc2cc(-c2ccc(cc2Cl)-c2cncs2)c1=O |
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| Structure | 
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