| Reaction Details |
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 | Report a problem with these data |
| Target | Intestinal-type alkaline phosphatase |
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| Ligand | BDBM222258 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Alkaline Phosphatase Assay |
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| pH | 9.8±n/a |
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| Temperature | 310.15±n/a K |
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| IC50 | 1.2e+2± 2e+1 nM |
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| Comments | extracted |
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| Citation |  Ejaz, SA; Saeed, A; Siddique, MN; Nisa, ZU; Khan, S; Lecka, J; Sévigny, J; Iqbal, J Synthesis, characterization and biological evaluation of novel chalcone sulfonamide hybrids as potent intestinal alkaline phosphatase inhibitors. Bioorg Chem70:229-236 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Intestinal-type alkaline phosphatase |
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| Name: | Intestinal-type alkaline phosphatase |
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| Synonyms: | ALPI | Intestinal alkaline phosphatase | Intestinal alkaline phosphatase (IAP) | Intestinal-type alkaline phosphatase (IAP) | PPBI_BOVIN |
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| Type: | Protein |
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| Mol. Mass.: | 57094.82 |
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| Organism: | Bos taurus (Cattle) |
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| Description: | P19111 |
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| Residue: | 533 |
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| Sequence: | MQGACVLLLLGLHLQLSLGLVPVEEEDPAFWNRQAAQALDVAKKLQPIQTAAKNVILFLG
DGMGVPTVTATRILKGQMNGKLGPETPLAMDQFPYVALSKTYNVDRQVPDSAGTATAYLC
GVKGNYRTIGVSAAARYNQCKTTRGNEVTSVMNRAKKAGKSVGVVTTTRVQHASPAGAYA
HTVNRNWYSDADLPADAQMNGCQDIAAQLVNNMDIDVILGGGRKYMFPVGTPDPEYPDDA
SVNGVRKRKQNLVQAWQAKHQGAQYVWNRTALLQAADDSSVTHLMGLFEPADMKYNVQQD
HTKDPTLQEMTEVALRVVSRNPRGFYLFVEGGRIDHGHHDDKAYMALTEAGMFDNAIAKA
NELTSELDTLILVTADHSHVFSFGGYTLRGTSIFGLAPSKALDSKSYTSILYGNGPGYAL
GGGSRPDVNDSTSEDPSYQQQAAVPQASETHGGEDVAVFARGPQAHLVHGVEEETFVAHI
MAFAGCVEPYTDCNLPAPTTATSIPDAAHLAASPPPLALLAGAMLLLLAPTLY
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| BDBM222258 |
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| n/a |
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| Name | BDBM222258 |
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| Synonyms: | (Z)-4-(2-((E)-4-(2-chlorophenyl)-1-morpholino-2-oxobut-3-enylidene)hydrazinyl) benzenesulfonamide (4a) |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21ClN4O4S |
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| Mol. Mass. | 448.923 |
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| SMILES | NS(=O)(=O)c1ccc(N\N=C(/N2CCOCC2)C(=O)\C=C\c2ccccc2Cl)cc1 |
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| Structure | 
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