| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Intestinal-type alkaline phosphatase |
|---|
| Ligand | BDBM222262 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Alkaline Phosphatase Assay |
|---|
| pH | 9.8±n/a |
|---|
| Temperature | 310.15±n/a K |
|---|
| IC50 | 3.5e+2± 2e+1 nM |
|---|
| Comments | extracted |
|---|
| Citation |  Ejaz, SA; Saeed, A; Siddique, MN; Nisa, ZU; Khan, S; Lecka, J; Sévigny, J; Iqbal, J Synthesis, characterization and biological evaluation of novel chalcone sulfonamide hybrids as potent intestinal alkaline phosphatase inhibitors. Bioorg Chem70:229-236 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Intestinal-type alkaline phosphatase |
|---|
| Name: | Intestinal-type alkaline phosphatase |
|---|
| Synonyms: | ALPI | Intestinal alkaline phosphatase | Intestinal alkaline phosphatase (IAP) | Intestinal-type alkaline phosphatase (IAP) | PPBI_BOVIN |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 57094.82 |
|---|
| Organism: | Bos taurus (Cattle) |
|---|
| Description: | P19111 |
|---|
| Residue: | 533 |
|---|
| Sequence: | MQGACVLLLLGLHLQLSLGLVPVEEEDPAFWNRQAAQALDVAKKLQPIQTAAKNVILFLG
DGMGVPTVTATRILKGQMNGKLGPETPLAMDQFPYVALSKTYNVDRQVPDSAGTATAYLC
GVKGNYRTIGVSAAARYNQCKTTRGNEVTSVMNRAKKAGKSVGVVTTTRVQHASPAGAYA
HTVNRNWYSDADLPADAQMNGCQDIAAQLVNNMDIDVILGGGRKYMFPVGTPDPEYPDDA
SVNGVRKRKQNLVQAWQAKHQGAQYVWNRTALLQAADDSSVTHLMGLFEPADMKYNVQQD
HTKDPTLQEMTEVALRVVSRNPRGFYLFVEGGRIDHGHHDDKAYMALTEAGMFDNAIAKA
NELTSELDTLILVTADHSHVFSFGGYTLRGTSIFGLAPSKALDSKSYTSILYGNGPGYAL
GGGSRPDVNDSTSEDPSYQQQAAVPQASETHGGEDVAVFARGPQAHLVHGVEEETFVAHI
MAFAGCVEPYTDCNLPAPTTATSIPDAAHLAASPPPLALLAGAMLLLLAPTLY
|
|
|
|---|
| BDBM222262 |
|---|
| n/a |
|---|
| Name | BDBM222262 |
|---|
| Synonyms: | (Z)-4-(2-((E)-4-(3,4-dimethoxyphenyl)-1-morpholino-2-oxobut-3-enylidene) hydrazinyl) benzenesulfonamide (4e) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H26N4O6S |
|---|
| Mol. Mass. | 474.53 |
|---|
| SMILES | COc1ccc(\C=C\C(=O)C(=N\Nc2ccc(cc2)S(N)(=O)=O)\N2CCOCC2)cc1OC |
|---|
| Structure | 
|
|---|
Search and Browse
