| Reaction Details |
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 | Report a problem with these data |
| Target | Transcription factor SOX-18 |
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| Ligand | BDBM17636 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Polarization Assay |
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| pH | 7.5±n/a |
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| Temperature | 310.15±n/a K |
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| IC50 | 2.20e+5± 6.86e+4 nM |
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| Comments | extracted |
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| Citation |  Fontaine, F; Overman, J; Moustaqil, M; Mamidyala, S; Salim, A; Narasimhan, K; Prokoph, N; Robertson, AA; Lua, L; Alexandrov, K; Koopman, P; Capon, RJ; Sierecki, E; Gambin, Y; Jauch, R; Cooper, MA; Zuegg, J; Francois, M Small-Molecule Inhibitors of the SOX18 Transcription Factor. Cell Chem Biol24:346-359 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transcription factor SOX-18 |
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| Name: | Transcription factor SOX-18 |
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| Synonyms: | SOX18_MOUSE | Sox-18 | Sox18 | Transcription factor SOX-18 (SOX-18) |
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| Type: | Protein |
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| Mol. Mass.: | 40900.72 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | P43680 |
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| Residue: | 377 |
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| Sequence: | MQRSPPGYGAQDDPPSRRDCAWAPGIGAAAEARGLPVTNVSPTSPASPSSLPRSPPRSPE
SGRYGFGRGERQTADELRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKEL
NTAEKRPFVEEAERLRVQHLRDHPNYKYRPRRKKQARKVRRLEPGLLLPGLVQPSAPPEA
FAAASGSARSFRELPTLGAEFDGLGLPTPERSPLDGLEPGEASFFPPPLAPEDCALRAFR
APYAPELARDPSFCYGAPLAEALRTAPPAAPLAGLYYGTLGTPGPFPNPLSPPPESPSLE
GTEQLEPTADLWADVDLTEFDQYLNCSRTRPDATTLPYHVALAKLGPRAMSCPEESSLIS
ALSDASSAVYYSACISG
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| BDBM17636 |
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| n/a |
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| Name | BDBM17636 |
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| Synonyms: | 2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid | Arlef | CHEMBL23588 | Flufenamic acid | Nichisedan | US20240002326, Compound Flufenamic acid | US9271961, Flufenamic Acid |
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| Type | Small organic molecule |
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| Emp. Form. | C14H10F3NO2 |
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| Mol. Mass. | 281.2299 |
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| SMILES | OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F |
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| Structure | 
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