BindingDB PrimarySearch

Found 30 hits with Last Name = 'mamidyala' and Initial = 's'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Dihydrofolate reductase (Homo sapiens (Human))	BDBM18069 (5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...) Show SMILES COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	123	n/a	n/a	n/a	n/a	n/a	n/a
University of Queensland Curated by ChEMBL					Assay Description Inhibition of DHFR using dihydrofolate as substrate following 3 mins substrate preincubation measured after 3 mins by spectrophotometric analysis				Bioorg Med Chem Lett 22: 2428-33 (2012) Article DOI: 10.1016/j.bmcl.2012.02.019 BindingDB Entry DOI: 10.7270/Q27082FG
University of Queensland Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50380095 (CHEMBL2012911) Show SMILES COc1cc(Cc2cnc(N)nc2N)cc2NCCOc12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	340	n/a	n/a	n/a	n/a	n/a	n/a
University of Queensland Curated by ChEMBL					Assay Description Inhibition of DHFR using dihydrofolate as substrate following 3 mins substrate preincubation measured after 3 mins by spectrophotometric analysis				Bioorg Med Chem Lett 22: 2428-33 (2012) Article DOI: 10.1016/j.bmcl.2012.02.019 BindingDB Entry DOI: 10.7270/Q27082FG
University of Queensland Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50380092 (CHEMBL2012918) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Queensland Curated by ChEMBL					Assay Description Inhibition of DHFR using dihydrofolate as substrate following 3 mins substrate preincubation measured after 3 mins by spectrophotometric analysis				Bioorg Med Chem Lett 22: 2428-33 (2012) Article DOI: 10.1016/j.bmcl.2012.02.019 BindingDB Entry DOI: 10.7270/Q27082FG
University of Queensland Curated by ChEMBL					More data for this Ligand-Target Pair
Transcription factor SOX-18 (Human)	BDBM223293 (Sm4 \| US20240002326, Compound Sm4) Show SMILES OC(=O)c1c(O)cccc1CCc1ccc2ccccc2c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem		n/a	n/a	9.75E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Transcription factor SOX-18 (Mus musculus (Mouse))	BDBM223293 (Sm4 \| US20240002326, Compound Sm4) Show SMILES OC(=O)c1c(O)cccc1CCc1ccc2ccccc2c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.75E+4	n/a	n/a	n/a	n/a	7.5	37
The University of Queensland					Assay Description The DNA-binding competition assay was performed in 25 μL, in black 384-well plates, using either 30 mM HEPES (N-2-Hydroxyethylpiperazine-N'-2-Etha...				Cell Chem Biol 24: 346-359 (2017) Article DOI: 10.1016/j.chembiol.2017.01.003 BindingDB Entry DOI: 10.7270/Q2MP5252
The University of Queensland					More data for this Ligand-Target Pair
Transcription factor SOX-18 (Human)	BDBM223299 (Sm14 \| US20240002326, Compound Sm14) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem		n/a	n/a	1.20E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Transcription factor SOX-18 (Mus musculus (Mouse))	BDBM223299 (Sm14 \| US20240002326, Compound Sm14) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20E+5	n/a	n/a	n/a	n/a	7.5	37
The University of Queensland					Assay Description The DNA-binding competition assay was performed in 25 μL, in black 384-well plates, using either 30 mM HEPES (N-2-Hydroxyethylpiperazine-N'-2-Etha...				Cell Chem Biol 24: 346-359 (2017) Article DOI: 10.1016/j.chembiol.2017.01.003 BindingDB Entry DOI: 10.7270/Q2MP5252
The University of Queensland					More data for this Ligand-Target Pair
Transcription factor SOX-18 (Human)	BDBM22971 (2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid...) Show SMILES Cc1ccc(Cl)c(Nc2ccccc2C(O)=O)c1Cl Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars		n/a	n/a	1.63E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Transcription factor SOX-18 (Mus musculus (Mouse))	BDBM22971 (2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid...) Show SMILES Cc1ccc(Cl)c(Nc2ccccc2C(O)=O)c1Cl Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.63E+5	n/a	n/a	n/a	n/a	7.5	37
The University of Queensland					Assay Description The DNA-binding competition assay was performed in 25 μL, in black 384-well plates, using either 30 mM HEPES (N-2-Hydroxyethylpiperazine-N'-2-Etha...				Cell Chem Biol 24: 346-359 (2017) Article DOI: 10.1016/j.chembiol.2017.01.003 BindingDB Entry DOI: 10.7270/Q2MP5252
The University of Queensland					More data for this Ligand-Target Pair
Transcription factor SOX-18 (Human)	BDBM17636 (2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid \|...) Show SMILES OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars		n/a	n/a	2.20E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Transcription factor SOX-18 (Mus musculus (Mouse))	BDBM17636 (2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid \|...) Show SMILES OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.20E+5	n/a	n/a	n/a	n/a	7.5	37
The University of Queensland					Assay Description The DNA-binding competition assay was performed in 25 μL, in black 384-well plates, using either 30 mM HEPES (N-2-Hydroxyethylpiperazine-N'-2-Etha...				Cell Chem Biol 24: 346-359 (2017) Article DOI: 10.1016/j.chembiol.2017.01.003 BindingDB Entry DOI: 10.7270/Q2MP5252
The University of Queensland					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50380096 (CHEMBL2012916) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>2.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Queensland Curated by ChEMBL					Assay Description Inhibition of DHFR using dihydrofolate as substrate following 3 mins substrate preincubation measured after 3 mins by spectrophotometric analysis				Bioorg Med Chem Lett 22: 2428-33 (2012) Article DOI: 10.1016/j.bmcl.2012.02.019 BindingDB Entry DOI: 10.7270/Q27082FG
University of Queensland Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50380094 (CHEMBL2012914) Show SMILES OC(=O)c1cn(C2CC2)c2nc(NCC#C)c(F)cc2c1=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Queensland Curated by ChEMBL					Assay Description Inhibition of DHFR using dihydrofolate as substrate following 3 mins substrate preincubation measured after 3 mins by spectrophotometric analysis				Bioorg Med Chem Lett 22: 2428-33 (2012) Article DOI: 10.1016/j.bmcl.2012.02.019 BindingDB Entry DOI: 10.7270/Q27082FG
University of Queensland Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50380093 (CHEMBL2012917) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Queensland Curated by ChEMBL					Assay Description Inhibition of DHFR using dihydrofolate as substrate following 3 mins substrate preincubation measured after 3 mins by spectrophotometric analysis				Bioorg Med Chem Lett 22: 2428-33 (2012) Article DOI: 10.1016/j.bmcl.2012.02.019 BindingDB Entry DOI: 10.7270/Q27082FG
University of Queensland Curated by ChEMBL					More data for this Ligand-Target Pair
Transcription factor SOX-18 (Mus musculus (Mouse))	BDBM223295 (Sm8 \| US20240002326, Compound Sm8) Show SMILES COc1cccc(CCCCCCc2ccccc2)c1C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.27E+5	n/a	n/a	n/a	n/a	7.5	37
The University of Queensland					Assay Description The DNA-binding competition assay was performed in 25 μL, in black 384-well plates, using either 30 mM HEPES (N-2-Hydroxyethylpiperazine-N'-2-Etha...				Cell Chem Biol 24: 346-359 (2017) Article DOI: 10.1016/j.chembiol.2017.01.003 BindingDB Entry DOI: 10.7270/Q2MP5252
The University of Queensland					More data for this Ligand-Target Pair
Transcription factor SOX-18 (Human)	BDBM223295 (Sm8 \| US20240002326, Compound Sm8) Show SMILES COc1cccc(CCCCCCc2ccccc2)c1C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem		n/a	n/a	3.27E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Transcription factor SOX-18 (Mus musculus (Mouse))	BDBM50259931 (6-Tridecylsalicylic acid (Sm2) \| 6-tridecyl phenol...) Show SMILES CCCCCCCCCCCCCc1cccc(O)c1C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.41E+5	n/a	n/a	n/a	n/a	7.5	37
The University of Queensland					Assay Description The DNA-binding competition assay was performed in 25 μL, in black 384-well plates, using either 30 mM HEPES (N-2-Hydroxyethylpiperazine-N'-2-Etha...				Cell Chem Biol 24: 346-359 (2017) Article DOI: 10.1016/j.chembiol.2017.01.003 BindingDB Entry DOI: 10.7270/Q2MP5252
The University of Queensland					More data for this Ligand-Target Pair
Transcription factor SOX-18 (Human)	BDBM50259931 (6-Tridecylsalicylic acid (Sm2) \| 6-tridecyl phenol...) Show SMILES CCCCCCCCCCCCCc1cccc(O)c1C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars		n/a	n/a	3.41E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Transcription factor SOX-18 (Human)	BDBM223292 (6-Undecylsalicylic acid (Sm1) \| US20240002326, Com...) Show SMILES CCCCCCCCCCCc1cccc(O)c1C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	3.48E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Transcription factor SOX-18 (Mus musculus (Mouse))	BDBM223292 (6-Undecylsalicylic acid (Sm1) \| US20240002326, Com...) Show SMILES CCCCCCCCCCCc1cccc(O)c1C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.48E+5	n/a	n/a	n/a	n/a	7.5	37
The University of Queensland					Assay Description The DNA-binding competition assay was performed in 25 μL, in black 384-well plates, using either 30 mM HEPES (N-2-Hydroxyethylpiperazine-N'-2-Etha...				Cell Chem Biol 24: 346-359 (2017) Article DOI: 10.1016/j.chembiol.2017.01.003 BindingDB Entry DOI: 10.7270/Q2MP5252
The University of Queensland					More data for this Ligand-Target Pair
Transcription factor SOX-18 (Mus musculus (Mouse))	BDBM85507 (CAS_4394-00-7 \| NSC_4488 \| Niflumic acid \| Niflumi...) Show SMILES OC(=O)c1cccnc1Nc1cccc(c1)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	3.75E+5	n/a	n/a	n/a	n/a	7.5	37
The University of Queensland					Assay Description The DNA-binding competition assay was performed in 25 μL, in black 384-well plates, using either 30 mM HEPES (N-2-Hydroxyethylpiperazine-N'-2-Etha...				Cell Chem Biol 24: 346-359 (2017) Article DOI: 10.1016/j.chembiol.2017.01.003 BindingDB Entry DOI: 10.7270/Q2MP5252
The University of Queensland					More data for this Ligand-Target Pair
Transcription factor SOX-18 (Human)	BDBM85507 (CAS_4394-00-7 \| NSC_4488 \| Niflumic acid \| Niflumi...) Show SMILES OC(=O)c1cccnc1Nc1cccc(c1)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents		n/a	n/a	3.75E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Transcription factor SOX-18 (Human)	BDBM223298 (Sm13 \| US20240002326, Compound Sm13) Show SMILES Cc1cccc2c1oc1cc(O)cc(O)c1c2=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem		n/a	n/a	4.81E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Transcription factor SOX-18 (Mus musculus (Mouse))	BDBM223298 (Sm13 \| US20240002326, Compound Sm13) Show SMILES Cc1cccc2c1oc1cc(O)cc(O)c1c2=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.81E+5	n/a	n/a	n/a	n/a	7.5	37
The University of Queensland					Assay Description The DNA-binding competition assay was performed in 25 μL, in black 384-well plates, using either 30 mM HEPES (N-2-Hydroxyethylpiperazine-N'-2-Etha...				Cell Chem Biol 24: 346-359 (2017) Article DOI: 10.1016/j.chembiol.2017.01.003 BindingDB Entry DOI: 10.7270/Q2MP5252
The University of Queensland					More data for this Ligand-Target Pair
Transcription factor SOX-18 (Human)	BDBM643023 (US20240002326, Compound Sm5) Show SMILES OC(=O)c1c(O)cccc1COCCc1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	1.11E+6	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Transcription factor SOX-18 (Mus musculus (Mouse))	BDBM223294 (Sm5) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.11E+6	n/a	n/a	n/a	n/a	7.5	37
The University of Queensland					Assay Description The DNA-binding competition assay was performed in 25 μL, in black 384-well plates, using either 30 mM HEPES (N-2-Hydroxyethylpiperazine-N'-2-Etha...				Cell Chem Biol 24: 346-359 (2017) Article DOI: 10.1016/j.chembiol.2017.01.003 BindingDB Entry DOI: 10.7270/Q2MP5252
The University of Queensland					More data for this Ligand-Target Pair
Transcription factor SOX-18 (Mus musculus (Mouse))	BDBM223297 (Sm12 \| US20240002326, Compound Sm12) Show SMILES Oc1ccc(C(=O)COc2ccc3ccccc3c2)c(O)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.88E+6	n/a	n/a	n/a	n/a	7.5	37
The University of Queensland					Assay Description The DNA-binding competition assay was performed in 25 μL, in black 384-well plates, using either 30 mM HEPES (N-2-Hydroxyethylpiperazine-N'-2-Etha...				Cell Chem Biol 24: 346-359 (2017) Article DOI: 10.1016/j.chembiol.2017.01.003 BindingDB Entry DOI: 10.7270/Q2MP5252
The University of Queensland					More data for this Ligand-Target Pair
Transcription factor SOX-18 (Human)	BDBM223297 (Sm12 \| US20240002326, Compound Sm12) Show SMILES Oc1ccc(C(=O)COc2ccc3ccccc3c2)c(O)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem		n/a	n/a	2.88E+6	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Transcription factor SOX-18 (Mus musculus (Mouse))	BDBM223296 (Sm11 \| US20240002326, Compound Sm11) Show SMILES COc1ccc(OCC(=O)c2ccc(O)cc2O)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.80E+6	n/a	n/a	n/a	n/a	7.5	37
The University of Queensland					Assay Description The DNA-binding competition assay was performed in 25 μL, in black 384-well plates, using either 30 mM HEPES (N-2-Hydroxyethylpiperazine-N'-2-Etha...				Cell Chem Biol 24: 346-359 (2017) Article DOI: 10.1016/j.chembiol.2017.01.003 BindingDB Entry DOI: 10.7270/Q2MP5252
The University of Queensland					More data for this Ligand-Target Pair
Transcription factor SOX-18 (Human)	BDBM223296 (Sm11 \| US20240002326, Compound Sm11) Show SMILES COc1ccc(OCC(=O)c2ccc(O)cc2O)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem		n/a	n/a	3.80E+6	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair