| Reaction Details |
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 | Report a problem with these data |
| Target | Mas-related G-protein coupled receptor member X2 |
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| Ligand | BDBM224020 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Intracellular Calcium Mobilization Assay |
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| pH | 7.4±0 |
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| Temperature | 303.15±0 K |
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| EC50 | 2.1e+4±1e+3 nM |
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| Citation |  Lansu, K; Karpiak, J; Liu, J; Huang, XP; McCorvy, JD; Kroeze, WK; Che, T; Nagase, H; Carroll, FI; Jin, J; Shoichet, BK; Roth, BL In silico design of novel probes for the atypical opioid receptor MRGPRX2. Nat Chem Biol13:529-536 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mas-related G-protein coupled receptor member X2 |
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| Name: | Mas-related G-protein coupled receptor member X2 |
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| Synonyms: | MRGPRX2 | MRGX2 | MRGX2_HUMAN | Mas-related G protein-coupled receptor X2 (MRGPRX2) | Mas-related G-protein coupled receptor member X2 |
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| Type: | GPCR |
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| Mol. Mass.: | 37104.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96LB1 |
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| Residue: | 330 |
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| Sequence: | MDPTTPAWGTESTTVNGNDQALLLLCGKETLIPVFLILFIALVGLVGNGFVLWLLGFRMR
RNAFSVYVLSLAGADFLFLCFQIINCLVYLSNFFCSISINFPSFFTTVMTCAYLAGLSML
STVSTERCLSVLWPIWYRCRRPRHLSAVVCVLLWALSLLLSILEGKFCGFLFSDGDSGWC
QTFDFITAAWLIFLFMVLCGSSLALLVRILCGSRGLPLTRLYLTILLTVLVFLLCGLPFG
IQWFLILWIWKDSDVLFCHIHPVSVVLSSLNSSANPIIYFFVGSFRKQWRLQQPILKLAL
QRALQDIAEVDHSEGCFRQGTPEMSRSSLV
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| BDBM224020 |
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| n/a |
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| Name | BDBM224020 |
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| Synonyms: | 6-Acetylmorphine |
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| Type | Small organic molecule |
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| Emp. Form. | C19H21NO4 |
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| Mol. Mass. | 327.3743 |
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| SMILES | CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3C=C[C@@H]4OC(C)=O)ccc5O |c:16| |
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| Structure | 
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