| Reaction Details |
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 | Report a problem with these data |
| Target | Mas-related G-protein coupled receptor member X2 |
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| Ligand | BDBM224025 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PRESTO-Tango Assay |
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| pH | 7.4±0 |
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| Temperature | 303.15±0 K |
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| EC50 | 2.1e+4±2.4e+4 nM |
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| Citation |  Lansu, K; Karpiak, J; Liu, J; Huang, XP; McCorvy, JD; Kroeze, WK; Che, T; Nagase, H; Carroll, FI; Jin, J; Shoichet, BK; Roth, BL In silico design of novel probes for the atypical opioid receptor MRGPRX2. Nat Chem Biol13:529-536 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mas-related G-protein coupled receptor member X2 |
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| Name: | Mas-related G-protein coupled receptor member X2 |
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| Synonyms: | MRGPRX2 | MRGX2 | MRGX2_HUMAN | Mas-related G protein-coupled receptor X2 (MRGPRX2) | Mas-related G-protein coupled receptor member X2 |
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| Type: | GPCR |
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| Mol. Mass.: | 37104.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96LB1 |
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| Residue: | 330 |
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| Sequence: | MDPTTPAWGTESTTVNGNDQALLLLCGKETLIPVFLILFIALVGLVGNGFVLWLLGFRMR
RNAFSVYVLSLAGADFLFLCFQIINCLVYLSNFFCSISINFPSFFTTVMTCAYLAGLSML
STVSTERCLSVLWPIWYRCRRPRHLSAVVCVLLWALSLLLSILEGKFCGFLFSDGDSGWC
QTFDFITAAWLIFLFMVLCGSSLALLVRILCGSRGLPLTRLYLTILLTVLVFLLCGLPFG
IQWFLILWIWKDSDVLFCHIHPVSVVLSSLNSSANPIIYFFVGSFRKQWRLQQPILKLAL
QRALQDIAEVDHSEGCFRQGTPEMSRSSLV
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| BDBM224025 |
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| n/a |
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| Name | BDBM224025 |
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| Synonyms: | Dynorphin A (1-17) | YGGFLRRXRPKLKWDNQ |
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| Type | Small organic molecule |
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| Emp. Form. | C99H155N31O23 |
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| Mol. Mass. | 2147.4839 |
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| SMILES | CCC(C)C(NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)C(N)Cc1ccc(O)cc1)C(=O)NC(CCCNC(N)=N)C(=O)N1CCCC1C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CCC(N)=O)C(O)=O |
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| Structure | 
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