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TargetTyrosine kinase receptor A (TrkA)
LigandBDBM226845
Substrate/Competitorn/a
Meas. Tech.Cell Based Assay
Temperature310.15±n/a K
IC50 4.46±n/a nM
Commentsextracted
Citation Bagal SKCui JJGreasley SELunney EAMcAlpine IJNagata ANinkovic SOmoto KSkerratt SEStorer RIWarmus JS Tropomyosin-related kinase inhibitors US Patent  US9328096 Publication Date 5/3/2016
More Info.:Get all data from this article,  Assay Method
 
Tyrosine kinase receptor A (TrkA)
Name:Tyrosine kinase receptor A (TrkA)
Synonyms:NTRK1 | Tyrosine kinase receptor A
Type:Protein
Mol. Mass.:39939.20
Organism:Homo sapiens (Human)
Description:Human his-tagged TrkA cytoplasmic domain (441-796 aa)
Residue:356
Sequence:
KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDA
CVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQRE
AELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPG
PLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDY
YRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCI
TQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG
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  Blast E-value cutoff:
BDBM226845
n/a
NameBDBM226845
Synonyms:US9328096, 538
TypeSmall organic molecule
Emp. Form.C28H24Cl2FN5O3
Mol. Mass.568.426
SMILESO[C@H]1CC[C@H](CC1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 |wU:1.0,4.7,(.23,-5.74,;-1.3,-5.57,;-2.2,-6.82,;-3.74,-6.66,;-4.36,-5.25,;-3.46,-4.01,;-1.93,-4.17,;-5.89,-5.09,;-6.52,-3.69,;-8.05,-3.52,;-5.62,-2.44,;-4.08,-2.44,;-3.6,-.97,;-2.14,-.5,;-.99,-1.53,;-1.31,-3.04,;.47,-1.05,;1.62,-2.08,;3.08,-1.61,;3.4,-.1,;4.87,.37,;2.26,.93,;.79,.45,;-.35,1.48,;4.23,-2.64,;3.91,-4.14,;5.05,-5.18,;6.52,-4.7,;6.84,-3.19,;5.69,-2.16,;6.01,-.66,;-4.85,-.07,;-6.09,-.97,;-4.85,1.47,;-6.18,2.24,;-6.18,3.78,;-4.85,4.55,;-3.51,3.78,;-3.51,2.24,)|
Structure
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