| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine kinase receptor A (TrkA) |
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| Ligand | BDBM226992 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Cell Based Assay |
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| Temperature | 310.15±n/a K |
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| IC50 | 2.65±n/a nM |
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| Comments | extracted |
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| Citation |  Bagal SK; Cui JJ; Greasley SE; Lunney EA; McAlpine IJ; Nagata A; Ninkovic S; Omoto K; Skerratt SE; Storer RI; Warmus JS Tropomyosin-related kinase inhibitors US Patent US9328096 Publication Date 5/3/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine kinase receptor A (TrkA) |
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| Name: | Tyrosine kinase receptor A (TrkA) |
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| Synonyms: | NTRK1 | Tyrosine kinase receptor A |
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| Type: | Protein |
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| Mol. Mass.: | 39939.20 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human his-tagged TrkA cytoplasmic domain (441-796 aa) |
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| Residue: | 356 |
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| Sequence: | KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDA
CVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQRE
AELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPG
PLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDY
YRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCI
TQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG
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| BDBM226992 |
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| n/a |
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| Name | BDBM226992 |
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| Synonyms: | US9328096, 680 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H23ClFN7O2 |
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| Mol. Mass. | 555.99 |
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| SMILES | Cc1ccc(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)c(N)n1 |
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| Structure | 
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