Reaction Details |
| Report a problem with these data |
Target | Carboxylic ester hydrolase |
---|
Ligand | BDBM227585 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | In Vitro AChE/BChE Inhibition Assay |
---|
pH | 7.4±n/a |
---|
Temperature | 298.15±n/a K |
---|
IC50 | 4.76±0.58 nM |
---|
Comments | extracted |
---|
Citation | Czarnecka, K; Szymanski, P; Girek, M; Mikiciuk-Olasik, E; Skibinski, R; Kabzinski, J; Majsterek, I; Malawska, B; Jonczyk, J; Bajda, M Tetrahydroacridine derivatives with fluorobenzoic acid moiety as multifunctional agents for Alzheimer's disease treatment. Bioorg Chem72:315-322 (2017) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Carboxylic ester hydrolase |
---|
Name: | Carboxylic ester hydrolase |
Synonyms: | BuChE | Butyrlcholinesterase (BuChE) | Butyrylcholine esterase | Butyrylcholinesterase | Butyrylcholinesterase (BChE) | Butyrylcholinesterase (BuChE) | Butyrylcholinesterase (EqBuChE) | Carboxylic ester hydrolase | butyrylcholinesterase precursor |
Type: | Protein |
Mol. Mass.: | 68842.83 |
Organism: | Equus caballus (Horse) |
Description: | Q9N1N9 |
Residue: | 602 |
Sequence: | MQSWGTIICIRILLRFLLLWVLIGNSHTEEDIIITTKNGKVRGMNLPVLGGTVTAFLGIP
YAQPPLGRLRFKKPQSLTKWSNIWNATKYANSCYQNTDQSFPGFLGSEMWNPNTELSEDC
LYLNVWIPAPKPKNATVMIWIYGGGFQTGTSSLPVYDGKFLARVERVIVVSMNYRVGALG
FLALSENPEAPGNMGLFDQQLALQWVQKNIAAFGGNPRSVTLFGESAGAASVSLHLLSPR
SQPLFTRAILQSGSSNAPWAVTSLYEARNRTLTLAKRMGCSRDNETEMIKCLRDKDPQEI
LLNEVFVVPYDTLLSVNFGPTVDGDFLTDMPDTLLQLGQFKRTQILVGVNKDEGTAFLVY
GAPGFSKDNNSIITRKEFQEGLKIFFPRVSEFGRESILFHYMDWLDDQRAENYREALDDV
VGDYNIICPALEFTKKFSELGNDAFFYYFEHRSTKLPWPEWMGVMHGYEIEFVFGLPLER
RVNYTKAEEILSRSIMKRWANFAKYGNPNGTQSNSTRWPVFKSTEQKYLTLNTESPKVYT
KLRAQQCRFWTLFFPKVLELTGNIDEAEREWKAGFHRWNNYMMDWKNQFNDYTSKKESCS
DF
|
|
|
BDBM227585 |
---|
n/a |
---|
Name | BDBM227585 |
Synonyms: | 3-Fluoro-N-[2-(1,2,3,4-tetrahydroacridin-9-ylamino)ethyl]benzamide hydrochloride (3d) |
Type | Small organic molecule |
Emp. Form. | C22H22FN3O |
Mol. Mass. | 363.428 |
SMILES | Fc1cccc(c1)C(=O)NCCNc1c2CCCCc2nc2ccccc12 |
Structure |
|