Reaction Details | |||
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Target | Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325] | ||
Ligand | BDBM231034 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Tankyrase Biochemical Assays | ||
Temperature | 298.15±n/a K | ||
IC50 | 3.56±n/a nM | ||
Comments | extracted | ||
Citation | Bregman, H; Buchanan, JL; Chakka, N; Dimauro, EF; Gunaydin, H; Guzman-Perez, A; Hua, Z; Huang, H; Huang, X; Martin, MW; Patel, VF Oxazolidinone compounds and derivatives thereof US Patent US9340549 Publication Date 5/17/2016 | ||
More Info.: | Get all data from this article, Assay Method | ||
Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325] | |||
Name: | Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325] | ||
Synonyms: | PARP5A | PARPL | TIN1 | TINF1 | TNKS | TNKS1 | TNKS1_HUMAN | Tankyrase-1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 26714.90 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O95271[1091-1325] | ||
Residue: | 235 | ||
Sequence: |
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BDBM231034 | |||
n/a | |||
Name | BDBM231034 | ||
Synonyms: | US9340549, 51 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H26N4O3 | ||
Mol. Mass. | 430.4989 | ||
SMILES | CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)n1c2cccc(C#N)c2[nH]c1=O |r,wU:7.8,14.15,wD:17.22,(-8.18,.02,;-6.84,.79,;-7.61,-.54,;-6.84,2.33,;-5.38,2.81,;-4.61,4.14,;-4.47,1.56,;-5.38,.32,;-4.98,-1.17,;-6.07,-2.26,;-5.67,-3.75,;-4.18,-4.14,;-3.09,-3.05,;-3.49,-1.57,;-2.93,1.56,;-2.16,2.9,;-.62,2.9,;.15,1.56,;-.62,.23,;-2.16,.23,;1.69,1.56,;2.59,.32,;2.27,-1.19,;3.42,-2.22,;4.88,-1.74,;5.2,-.24,;6.67,.24,;8.13,.72,;4.06,.79,;4.06,2.33,;2.59,2.81,;1.82,4.14,)| | ||
Structure |