Ki Summary

Reaction Details

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Target

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Ligand

BDBM231037

Substrate/Competitor

n/a

Meas. Tech.

Tankyrase Biochemical Assays

Temperature

298.15±n/a K

IC50

7.42±n/a nM

Comments

extracted

Citation

Bregman, H; Buchanan, JL; Chakka, N; Dimauro, EF; Gunaydin, H; Guzman-Perez, A; Hua, Z; Huang, H; Huang, X; Martin, MW; Patel, VF Oxazolidinone compounds and derivatives thereof US Patent US9340549 Publication Date 5/17/2016

More Info.:

Get all data from this article, Assay Method

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Name:

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Synonyms:

Type:

Enzyme

Mol. Mass.:

26714.90

Organism:

Homo sapiens (Human)

Description:

O95271[1091-1325]

Residue:

235

Sequence:

QGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRI
QKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGA
GIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAH
APPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQ

BDBM231037

n/a

Name

BDBM231037

Synonyms:

US9340549, 54

Type

Small organic molecule

Emp. Form.

C24H25N5O3

Mol. Mass.

431.487

SMILES

CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)n1c2cc(ncc2[nH]c1=O)C#N |r,wU:7.8,17.22,wD:14.15,(-6.69,.55,;-5.36,1.32,;-6.13,-.01,;-5.36,2.86,;-3.89,3.33,;-3.12,4.67,;-2.99,2.09,;-3.89,.84,;-3.49,-.64,;-4.58,-1.73,;-4.18,-3.22,;-2.69,-3.62,;-1.61,-2.53,;-2,-1.04,;-1.45,2.09,;-.68,.76,;.86,.76,;1.63,2.09,;.86,3.42,;-.68,3.42,;3.17,2.09,;4.08,.84,;3.76,-.66,;4.9,-1.69,;6.37,-1.22,;6.69,.29,;5.54,1.32,;5.54,2.86,;4.08,3.33,;3.31,4.67,;4.58,-3.2,;4.26,-4.71,)|

Structure