Ki Summary

Reaction Details

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Target

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Ligand

BDBM231041

Substrate/Competitor

n/a

Meas. Tech.

Tankyrase Biochemical Assays

Temperature

298.15±n/a K

IC50

7.46±n/a nM

Comments

extracted

Citation

Bregman, H; Buchanan, JL; Chakka, N; Dimauro, EF; Gunaydin, H; Guzman-Perez, A; Hua, Z; Huang, H; Huang, X; Martin, MW; Patel, VF Oxazolidinone compounds and derivatives thereof US Patent US9340549 Publication Date 5/17/2016

More Info.:

Get all data from this article, Assay Method

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Name:

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Synonyms:

Type:

Enzyme

Mol. Mass.:

26714.90

Organism:

Homo sapiens (Human)

Description:

O95271[1091-1325]

Residue:

235

Sequence:

QGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRI
QKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGA
GIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAH
APPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQ

BDBM231041

n/a

Name

BDBM231041

Synonyms:

US9340549, 58

Type

Small organic molecule

Emp. Form.

C25H28N4O3

Mol. Mass.

432.5148

SMILES

CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)n1ccc2cccnc12 |r,wU:7.8,17.22,wD:14.15,(-7.38,-.02,;-6.04,.75,;-6.81,-.58,;-6.04,2.29,;-4.58,2.77,;-3.81,4.1,;-3.67,1.52,;-4.58,.27,;-4.18,-1.21,;-5.27,-2.3,;-4.87,-3.79,;-3.38,-4.19,;-2.29,-3.1,;-2.69,-1.61,;-2.13,1.52,;-1.36,.19,;.18,.19,;.95,1.52,;.18,2.85,;-1.36,2.85,;2.49,1.52,;3.26,2.85,;2.49,4.19,;4.59,2.08,;5.84,2.99,;7.08,2.08,;6.61,.62,;7.38,-.71,;6.61,-2.05,;5.07,-2.05,;4.3,-.71,;5.07,.62,)|

Structure