Ki Summary

Reaction Details

Report a problem with these data

Target

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Ligand

BDBM231043

Substrate/Competitor

n/a

Meas. Tech.

Tankyrase Biochemical Assays

Temperature

298.15±n/a K

IC50

7.63±n/a nM

Comments

extracted

Citation

Bregman, H; Buchanan, JL; Chakka, N; Dimauro, EF; Gunaydin, H; Guzman-Perez, A; Hua, Z; Huang, H; Huang, X; Martin, MW; Patel, VF Oxazolidinone compounds and derivatives thereof US Patent US9340549 Publication Date 5/17/2016

More Info.:

Get all data from this article, Assay Method

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Name:

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Synonyms:

Type:

Enzyme

Mol. Mass.:

26714.90

Organism:

Homo sapiens (Human)

Description:

O95271[1091-1325]

Residue:

235

Sequence:

QGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRI
QKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGA
GIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAH
APPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQ

BDBM231043

n/a

Name

BDBM231043

Synonyms:

US9340549, 62

Type

Small organic molecule

Emp. Form.

C26H28N4O3

Mol. Mass.

444.5255

SMILES

CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)N1Cc2cc(ccc2NC1=O)C#N |r,wU:7.8,17.22,wD:14.15,(-8.01,-.02,;-6.68,.75,;-7.45,-.58,;-6.68,2.29,;-5.21,2.77,;-4.44,4.1,;-4.31,1.52,;-5.21,.27,;-4.81,-1.21,;-5.9,-2.3,;-5.51,-3.79,;-4.02,-4.19,;-2.93,-3.1,;-3.33,-1.61,;-2.77,1.52,;-2,.19,;-.46,.19,;.31,1.52,;-.46,2.85,;-2,2.85,;1.85,1.52,;2.62,.19,;4.16,.19,;4.93,-1.15,;6.47,-1.15,;7.24,.19,;6.47,1.52,;4.93,1.52,;4.16,2.85,;2.62,2.85,;1.85,4.19,;7.24,-2.48,;8.01,-3.81,)|

Structure