Ki Summary

Reaction Details

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Target

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Ligand

BDBM231063

Substrate/Competitor

n/a

Meas. Tech.

Tankyrase Biochemical Assays

Temperature

298.15±n/a K

IC50

32.2±n/a nM

Comments

extracted

Citation

Bregman, H; Buchanan, JL; Chakka, N; Dimauro, EF; Gunaydin, H; Guzman-Perez, A; Hua, Z; Huang, H; Huang, X; Martin, MW; Patel, VF Oxazolidinone compounds and derivatives thereof US Patent US9340549 Publication Date 5/17/2016

More Info.:

Get all data from this article, Assay Method

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Name:

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Synonyms:

Type:

Enzyme

Mol. Mass.:

26714.90

Organism:

Homo sapiens (Human)

Description:

O95271[1091-1325]

Residue:

235

Sequence:

QGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRI
QKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGA
GIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAH
APPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQ

BDBM231063

n/a

Name

BDBM231063

Synonyms:

US9340549, 86

Type

Small organic molecule

Emp. Form.

C25H27N3O3

Mol. Mass.

417.5002

SMILES

CC1(C)OC(=O)N([C@@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)c1nnc(o1)-c1ccccc1 |r,wU:14.15,wD:7.8,17.22,(-7.95,.02,;-6.62,.79,;-7.39,-.54,;-6.62,2.33,;-5.15,2.81,;-4.38,4.14,;-4.25,1.56,;-5.15,.32,;-4.75,-1.17,;-5.84,-2.26,;-5.44,-3.75,;-3.96,-4.14,;-2.87,-3.05,;-3.26,-1.57,;-2.71,1.56,;-1.94,2.9,;-.4,2.9,;.37,1.56,;-.4,.23,;-1.94,.23,;1.91,1.56,;2.82,2.81,;4.28,2.33,;4.28,.79,;2.82,.32,;5.37,-.29,;4.97,-1.78,;6.06,-2.87,;7.55,-2.47,;7.95,-.98,;6.86,.1,)|

Structure