Ki Summary

Reaction Details

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Target

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Ligand

BDBM231067

Substrate/Competitor

n/a

Meas. Tech.

Tankyrase Biochemical Assays

Temperature

298.15±n/a K

IC50

772±n/a nM

Comments

extracted

Citation

Bregman, H; Buchanan, JL; Chakka, N; Dimauro, EF; Gunaydin, H; Guzman-Perez, A; Hua, Z; Huang, H; Huang, X; Martin, MW; Patel, VF Oxazolidinone compounds and derivatives thereof US Patent US9340549 Publication Date 5/17/2016

More Info.:

Get all data from this article, Assay Method

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Name:

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Synonyms:

Type:

Enzyme

Mol. Mass.:

26714.90

Organism:

Homo sapiens (Human)

Description:

O95271[1091-1325]

Residue:

235

Sequence:

QGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRI
QKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGA
GIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAH
APPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQ

BDBM231067

n/a

Name

BDBM231067

Synonyms:

US9340549, 90

Type

Small organic molecule

Emp. Form.

C22H24N4O3

Mol. Mass.

392.451

SMILES

C[C@]1(CN([C@H]2CC[C@@H](CC2)n2c3ccncc3[nH]c2=O)C(=O)O1)c1ccccc1 |r,wU:4.3,wD:1.0,7.10,(-4.58,-1.5,;-3.81,-.17,;-2.34,-.64,;-1.44,.6,;.1,.6,;.87,1.94,;2.41,1.94,;3.18,.6,;2.41,-.73,;.87,-.73,;4.72,.6,;5.63,-.64,;5.31,-2.15,;6.45,-3.18,;7.92,-2.71,;8.24,-1.2,;7.09,-.17,;7.09,1.37,;5.63,1.85,;4.86,3.18,;-2.34,1.85,;-1.57,3.18,;-3.81,1.37,;-5.35,-.17,;-6.12,1.17,;-7.66,1.17,;-8.43,-.17,;-7.66,-1.5,;-6.12,-1.5,)|

Structure