Ki Summary

Reaction Details

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Target

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Ligand

BDBM231079

Substrate/Competitor

n/a

Meas. Tech.

Tankyrase Biochemical Assays

Temperature

298.15±n/a K

IC50

93±n/a nM

Comments

extracted

Citation

Bregman, H; Buchanan, JL; Chakka, N; Dimauro, EF; Gunaydin, H; Guzman-Perez, A; Hua, Z; Huang, H; Huang, X; Martin, MW; Patel, VF Oxazolidinone compounds and derivatives thereof US Patent US9340549 Publication Date 5/17/2016

More Info.:

Get all data from this article, Assay Method

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Name:

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Synonyms:

Type:

Enzyme

Mol. Mass.:

26714.90

Organism:

Homo sapiens (Human)

Description:

O95271[1091-1325]

Residue:

235

Sequence:

QGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRI
QKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGA
GIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAH
APPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQ

BDBM231079

n/a

Name

BDBM231079

Synonyms:

US9340549, 104

Type

Small organic molecule

Emp. Form.

C24H25F2N3O3

Mol. Mass.

441.4704

SMILES

CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)n1c2cc(F)cc(F)c2[nH]c1=O |r,wU:7.8,14.15,wD:17.22,(-7.43,.02,;-6.1,.79,;-6.87,-.54,;-6.1,2.33,;-4.63,2.81,;-3.86,4.14,;-3.73,1.56,;-4.63,.32,;-4.24,-1.17,;-5.32,-2.26,;-4.93,-3.75,;-3.44,-4.14,;-2.35,-3.05,;-2.75,-1.57,;-2.19,1.56,;-1.42,2.9,;.12,2.9,;.89,1.56,;.12,.23,;-1.42,.23,;2.43,1.56,;3.34,.32,;3.02,-1.19,;4.16,-2.22,;3.76,-3.71,;5.63,-1.74,;5.95,-.24,;7.43,.16,;4.8,.79,;4.8,2.33,;3.34,2.81,;2.57,4.14,)|

Structure