Ki Summary

Reaction Details

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Target

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Ligand

BDBM231108

Substrate/Competitor

n/a

Meas. Tech.

Tankyrase Biochemical Assays

Temperature

298.15±n/a K

IC50

1380±n/a nM

Comments

extracted

Citation

Bregman, H; Buchanan, JL; Chakka, N; Dimauro, EF; Gunaydin, H; Guzman-Perez, A; Hua, Z; Huang, H; Huang, X; Martin, MW; Patel, VF Oxazolidinone compounds and derivatives thereof US Patent US9340549 Publication Date 5/17/2016

More Info.:

Get all data from this article, Assay Method

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Name:

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Synonyms:

Type:

Enzyme

Mol. Mass.:

26714.90

Organism:

Homo sapiens (Human)

Description:

O95271[1091-1325]

Residue:

235

Sequence:

QGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRI
QKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGA
GIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAH
APPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQ

BDBM231108

n/a

Name

BDBM231108

Synonyms:

US9340549, 133

Type

Small organic molecule

Emp. Form.

C22H26N2O2

Mol. Mass.

350.454

SMILES

CC1(C)OC(=O)N([C@H]1c1ccccc1)C1CC[C@@H](CC1)c1cccnc1 |r,wU:7.8,17.22,(-6.47,.02,;-5.14,.79,;-5.91,-.54,;-5.14,2.33,;-3.67,2.81,;-2.9,4.14,;-2.77,1.56,;-3.67,.32,;-3.27,-1.17,;-4.36,-2.26,;-3.97,-3.75,;-2.48,-4.14,;-1.39,-3.05,;-1.79,-1.57,;-1.23,1.56,;-.46,.23,;1.08,.23,;1.85,1.56,;1.08,2.9,;-.46,2.9,;3.39,1.56,;4.16,.23,;5.7,.23,;6.47,1.56,;5.7,2.9,;4.16,2.9,)|

Structure