Reaction Details | |||
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Target | Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325] | ||
Ligand | BDBM231113 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Tankyrase Biochemical Assays | ||
Temperature | 298.15±n/a K | ||
IC50 | 1250±n/a nM | ||
Comments | extracted | ||
Citation | Bregman, H; Buchanan, JL; Chakka, N; Dimauro, EF; Gunaydin, H; Guzman-Perez, A; Hua, Z; Huang, H; Huang, X; Martin, MW; Patel, VF Oxazolidinone compounds and derivatives thereof US Patent US9340549 Publication Date 5/17/2016 | ||
More Info.: | Get all data from this article, Assay Method | ||
Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325] | |||
Name: | Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325] | ||
Synonyms: | PARP5A | PARPL | TIN1 | TINF1 | TNKS | TNKS1 | TNKS1_HUMAN | Tankyrase-1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 26714.90 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O95271[1091-1325] | ||
Residue: | 235 | ||
Sequence: |
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BDBM231113 | |||
n/a | |||
Name | BDBM231113 | ||
Synonyms: | US9340549, 138 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H27N3O3 | ||
Mol. Mass. | 417.5002 | ||
SMILES | CC1(C)OC(=O)N([C@H]1c1ccccc1)C1CC[C@@H](CC1)c1cc2ccncc2[nH]c1=O |r,wU:7.8,wD:17.22,(-7.63,-.02,;-6.29,.75,;-7.06,-.58,;-6.29,2.29,;-4.83,2.77,;-4.06,4.1,;-3.92,1.52,;-4.83,.27,;-4.43,-1.21,;-5.52,-2.3,;-5.12,-3.79,;-3.63,-4.19,;-2.54,-3.1,;-2.94,-1.61,;-2.38,1.52,;-1.61,2.85,;-.07,2.85,;.7,1.52,;-.07,.19,;-1.61,.19,;2.24,1.52,;3.01,.19,;4.55,.19,;5.32,-1.15,;6.86,-1.15,;7.63,.19,;6.86,1.52,;5.32,1.52,;4.55,2.85,;3.01,2.85,;2.24,4.19,)| | ||
Structure |