Ki Summary

Reaction Details

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Target

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Ligand

BDBM231116

Substrate/Competitor

n/a

Meas. Tech.

Tankyrase Biochemical Assays

Temperature

298.15±n/a K

IC50

755±n/a nM

Comments

extracted

Citation

Bregman, H; Buchanan, JL; Chakka, N; Dimauro, EF; Gunaydin, H; Guzman-Perez, A; Hua, Z; Huang, H; Huang, X; Martin, MW; Patel, VF Oxazolidinone compounds and derivatives thereof US Patent US9340549 Publication Date 5/17/2016

More Info.:

Get all data from this article, Assay Method

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Name:

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Synonyms:

Type:

Enzyme

Mol. Mass.:

26714.90

Organism:

Homo sapiens (Human)

Description:

O95271[1091-1325]

Residue:

235

Sequence:

QGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRI
QKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGA
GIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAH
APPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQ

BDBM231116

n/a

Name

BDBM231116

Synonyms:

US9340549, 141

Type

Small organic molecule

Emp. Form.

C24H28N2O3

Mol. Mass.

392.4907

SMILES

CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1ccccc1 |r,wU:17.22,7.8,wD:14.15,(-7.16,3.08,;-5.83,2.31,;-7.16,1.54,;-4.92,3.56,;-3.46,3.08,;-2.13,3.85,;-3.46,1.54,;-4.92,1.06,;-5.32,-.42,;-6.81,-.82,;-7.21,-2.31,;-6.12,-3.4,;-4.63,-3,;-4.23,-1.51,;-2.13,.77,;-2.13,-.77,;-.79,-1.54,;.54,-.77,;.54,.77,;-.79,1.54,;1.87,-1.54,;3.21,-.77,;3.21,.77,;4.54,-1.54,;4.54,-3.08,;5.88,-3.85,;7.21,-3.08,;7.21,-1.54,;5.88,-.77,)|

Structure