Ki Summary

Reaction Details

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Target

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Ligand

BDBM231122

Substrate/Competitor

n/a

Meas. Tech.

Tankyrase Biochemical Assays

Temperature

298.15±n/a K

IC50

26.4±n/a nM

Comments

extracted

Citation

Bregman, H; Buchanan, JL; Chakka, N; Dimauro, EF; Gunaydin, H; Guzman-Perez, A; Hua, Z; Huang, H; Huang, X; Martin, MW; Patel, VF Oxazolidinone compounds and derivatives thereof US Patent US9340549 Publication Date 5/17/2016

More Info.:

Get all data from this article, Assay Method

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Name:

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Synonyms:

Type:

Enzyme

Mol. Mass.:

26714.90

Organism:

Homo sapiens (Human)

Description:

O95271[1091-1325]

Residue:

235

Sequence:

QGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRI
QKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGA
GIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAH
APPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQ

BDBM231122

n/a

Name

BDBM231122

Synonyms:

US9340549, 147

Type

Small organic molecule

Emp. Form.

C25H28N4O3

Mol. Mass.

432.5148

SMILES

CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1ccc2cc[nH]c2n1 |r,wU:7.8,17.22,wD:14.15,(-8.46,-.59,;-7.13,.18,;-7.9,-1.16,;-7.13,1.72,;-5.66,2.19,;-4.89,3.53,;-4.76,.95,;-5.66,-.3,;-5.26,-1.79,;-6.35,-2.87,;-5.95,-4.36,;-4.47,-4.76,;-3.38,-3.67,;-3.78,-2.18,;-3.22,.95,;-2.45,-.39,;-.91,-.39,;-.14,.95,;-.91,2.28,;-2.45,2.28,;1.4,.95,;2.17,2.28,;1.4,3.62,;3.71,2.28,;4.48,.95,;6.02,.95,;6.79,2.28,;8.3,2.6,;8.46,4.13,;7.05,4.76,;6.02,3.62,;4.48,3.62,)|

Structure