Ki Summary

Reaction Details

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Target

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Ligand

BDBM231129

Substrate/Competitor

n/a

Meas. Tech.

Tankyrase Biochemical Assays

Temperature

298.15±n/a K

IC50

2320±n/a nM

Comments

extracted

Citation

Bregman, H; Buchanan, JL; Chakka, N; Dimauro, EF; Gunaydin, H; Guzman-Perez, A; Hua, Z; Huang, H; Huang, X; Martin, MW; Patel, VF Oxazolidinone compounds and derivatives thereof US Patent US9340549 Publication Date 5/17/2016

More Info.:

Get all data from this article, Assay Method

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Name:

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Synonyms:

Type:

Enzyme

Mol. Mass.:

26714.90

Organism:

Homo sapiens (Human)

Description:

O95271[1091-1325]

Residue:

235

Sequence:

QGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRI
QKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGA
GIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAH
APPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQ

BDBM231129

n/a

Name

BDBM231129

Synonyms:

US9340549, 154

Type

Small organic molecule

Emp. Form.

C24H32N4O3

Mol. Mass.

424.5359

SMILES

CC(C)c1cc([nH]n1)C(=O)N[C@H]1CC[C@@H](CC1)N1[C@@H](c2ccccc2)C(C)(C)OC1=O |r,wU:18.20,11.11,wD:14.18,(8.61,2.08,;7.27,1.31,;7.27,-.23,;5.94,2.08,;4.47,1.61,;3.57,2.85,;4.47,4.1,;5.94,3.62,;2.03,2.85,;1.26,4.19,;1.26,1.52,;-.28,1.52,;-1.05,.19,;-2.59,.19,;-3.36,1.52,;-2.59,2.85,;-1.05,2.85,;-4.9,1.52,;-5.81,.27,;-5.41,-1.21,;-6.5,-2.3,;-6.1,-3.79,;-4.61,-4.19,;-3.52,-3.1,;-3.92,-1.61,;-7.27,.75,;-8.61,-.02,;-8.04,-.58,;-7.27,2.29,;-5.81,2.77,;-5.04,4.1,)|

Structure