Ki Summary

Reaction Details

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Target

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Ligand

BDBM231132

Substrate/Competitor

n/a

Meas. Tech.

Tankyrase Biochemical Assays

Temperature

298.15±n/a K

IC50

76.8±n/a nM

Comments

extracted

Citation

Bregman, H; Buchanan, JL; Chakka, N; Dimauro, EF; Gunaydin, H; Guzman-Perez, A; Hua, Z; Huang, H; Huang, X; Martin, MW; Patel, VF Oxazolidinone compounds and derivatives thereof US Patent US9340549 Publication Date 5/17/2016

More Info.:

Get all data from this article, Assay Method

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Name:

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Synonyms:

Type:

Enzyme

Mol. Mass.:

26714.90

Organism:

Homo sapiens (Human)

Description:

O95271[1091-1325]

Residue:

235

Sequence:

QGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRI
QKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGA
GIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAH
APPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQ

BDBM231132

n/a

Name

BDBM231132

Synonyms:

US9340549, 157

Type

Small organic molecule

Emp. Form.

C25H28N4O3

Mol. Mass.

432.5148

SMILES

CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1nc2ccccc2[nH]1 |r,wU:7.8,17.22,wD:14.15,(-8.61,-.12,;-7.27,.65,;-8.04,-.69,;-7.27,2.19,;-5.81,2.66,;-5.04,4,;-4.9,1.42,;-5.81,.17,;-5.41,-1.32,;-6.5,-2.41,;-6.1,-3.89,;-4.61,-4.29,;-3.52,-3.2,;-3.92,-1.71,;-3.36,1.42,;-2.59,.08,;-1.05,.08,;-.28,1.42,;-1.05,2.75,;-2.59,2.75,;1.26,1.42,;2.03,2.75,;1.26,4.08,;3.57,2.75,;4.47,4,;5.94,3.52,;7.27,4.29,;8.61,3.52,;8.61,1.98,;7.27,1.21,;5.94,1.98,;4.47,1.51,)|

Structure