Reaction Details | |||
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Target | Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325] | ||
Ligand | BDBM231133 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Tankyrase Biochemical Assays | ||
Temperature | 298.15±n/a K | ||
IC50 | 142±n/a nM | ||
Comments | extracted | ||
Citation | Bregman, H; Buchanan, JL; Chakka, N; Dimauro, EF; Gunaydin, H; Guzman-Perez, A; Hua, Z; Huang, H; Huang, X; Martin, MW; Patel, VF Oxazolidinone compounds and derivatives thereof US Patent US9340549 Publication Date 5/17/2016 | ||
More Info.: | Get all data from this article, Assay Method | ||
Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325] | |||
Name: | Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325] | ||
Synonyms: | PARP5A | PARPL | TIN1 | TINF1 | TNKS | TNKS1 | TNKS1_HUMAN | Tankyrase-1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 26714.90 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O95271[1091-1325] | ||
Residue: | 235 | ||
Sequence: |
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BDBM231133 | |||
n/a | |||
Name | BDBM231133 | ||
Synonyms: | US9340549, 158 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H27N3O3 | ||
Mol. Mass. | 381.4681 | ||
SMILES | CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1ccc[nH]1 |r,wU:7.8,17.22,wD:14.15,(-7.27,-.02,;-5.94,.75,;-6.71,-.58,;-5.94,2.29,;-4.47,2.77,;-3.7,4.1,;-3.57,1.52,;-4.47,.27,;-4.07,-1.21,;-5.16,-2.3,;-4.77,-3.79,;-3.28,-4.19,;-2.19,-3.1,;-2.59,-1.61,;-2.03,1.52,;-1.26,.19,;.28,.19,;1.05,1.52,;.28,2.85,;-1.26,2.85,;2.59,1.52,;3.36,2.85,;2.59,4.19,;4.9,2.85,;5.81,1.61,;7.27,2.08,;7.27,3.62,;5.81,4.1,)| | ||
Structure |