Reaction Details | |||
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Target | Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325] | ||
Ligand | BDBM231137 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Tankyrase Biochemical Assays | ||
Temperature | 298.15±n/a K | ||
IC50 | 101±n/a nM | ||
Comments | extracted | ||
Citation | Bregman, H; Buchanan, JL; Chakka, N; Dimauro, EF; Gunaydin, H; Guzman-Perez, A; Hua, Z; Huang, H; Huang, X; Martin, MW; Patel, VF Oxazolidinone compounds and derivatives thereof US Patent US9340549 Publication Date 5/17/2016 | ||
More Info.: | Get all data from this article, Assay Method | ||
Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325] | |||
Name: | Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325] | ||
Synonyms: | PARP5A | PARPL | TIN1 | TINF1 | TNKS | TNKS1 | TNKS1_HUMAN | Tankyrase-1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 26714.90 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O95271[1091-1325] | ||
Residue: | 235 | ||
Sequence: |
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BDBM231137 | |||
n/a | |||
Name | BDBM231137 | ||
Synonyms: | US9340549, 162 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H28N4O3 | ||
Mol. Mass. | 432.5148 | ||
SMILES | CC1(C)OC(=O)N([C@@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)NC(=O)c1cn2ccccc2n1 |r,wU:14.15,wD:7.8,17.22,(-8.61,-.12,;-7.27,.65,;-8.04,-.69,;-7.27,2.19,;-5.81,2.66,;-5.04,4,;-4.9,1.42,;-5.81,.17,;-5.41,-1.32,;-6.5,-2.41,;-6.1,-3.89,;-4.61,-4.29,;-3.52,-3.2,;-3.92,-1.71,;-3.36,1.42,;-2.59,2.75,;-1.05,2.75,;-.28,1.42,;-1.05,.08,;-2.59,.08,;1.26,1.42,;2.03,2.75,;1.26,4.08,;3.57,2.75,;4.47,1.51,;5.94,1.98,;7.27,1.21,;8.61,1.98,;8.61,3.52,;7.27,4.29,;5.94,3.52,;4.47,4,)| | ||
Structure |