Ki Summary

Reaction Details

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Target

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Ligand

BDBM231138

Substrate/Competitor

n/a

Meas. Tech.

Tankyrase Biochemical Assays

Temperature

298.15±n/a K

IC50

220±n/a nM

Comments

extracted

Citation

Bregman, H; Buchanan, JL; Chakka, N; Dimauro, EF; Gunaydin, H; Guzman-Perez, A; Hua, Z; Huang, H; Huang, X; Martin, MW; Patel, VF Oxazolidinone compounds and derivatives thereof US Patent US9340549 Publication Date 5/17/2016

More Info.:

Get all data from this article, Assay Method

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Name:

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Synonyms:

Type:

Enzyme

Mol. Mass.:

26714.90

Organism:

Homo sapiens (Human)

Description:

O95271[1091-1325]

Residue:

235

Sequence:

QGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRI
QKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGA
GIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAH
APPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQ

BDBM231138

n/a

Name

BDBM231138

Synonyms:

US9340549, 163

Type

Small organic molecule

Emp. Form.

C25H30N2O4

Mol. Mass.

422.5167

SMILES

COc1ccccc1C(=O)N[C@H]1CC[C@@H](CC1)N1[C@@H](c2ccccc2)C(C)(C)OC1=O |r,wU:18.20,11.11,wD:14.18,(5.32,5.52,;4.55,4.19,;5.32,2.85,;6.86,2.85,;7.63,1.52,;6.86,.19,;5.32,.19,;4.55,1.52,;3.01,1.52,;2.24,2.85,;2.24,.19,;.7,.19,;-.07,-1.15,;-1.61,-1.15,;-2.38,.19,;-1.61,1.52,;-.07,1.52,;-3.92,.19,;-4.83,-1.06,;-4.43,-2.55,;-5.52,-3.64,;-5.12,-5.12,;-3.63,-5.52,;-2.54,-4.43,;-2.94,-2.95,;-6.29,-.58,;-7.63,-1.35,;-7.06,-1.92,;-6.29,.96,;-4.83,1.43,;-4.06,2.77,)|

Structure