Ki Summary

Reaction Details

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Target

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Ligand

BDBM231149

Substrate/Competitor

n/a

Meas. Tech.

Tankyrase Biochemical Assays

Temperature

298.15±n/a K

IC50

1250±n/a nM

Comments

extracted

Citation

Bregman, H; Buchanan, JL; Chakka, N; Dimauro, EF; Gunaydin, H; Guzman-Perez, A; Hua, Z; Huang, H; Huang, X; Martin, MW; Patel, VF Oxazolidinone compounds and derivatives thereof US Patent US9340549 Publication Date 5/17/2016

More Info.:

Get all data from this article, Assay Method

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Name:

Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325]

Synonyms:

Type:

Enzyme

Mol. Mass.:

26714.90

Organism:

Homo sapiens (Human)

Description:

O95271[1091-1325]

Residue:

235

Sequence:

QGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRI
QKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGA
GIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAH
APPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQ

BDBM231149

n/a

Name

BDBM231149

Synonyms:

US9340549, 172

Type

Small organic molecule

Emp. Form.

C24H27N3O2

Mol. Mass.

389.4901

SMILES

CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@H](CC1)c1cnc2cc[nH]c2c1 |r,wU:7.8,wD:14.15,17.22,(-6.24,-3.44,;-5.47,-2.11,;-4.7,-3.44,;-6.37,-.86,;-5.47,.38,;-6.24,1.72,;-4,-.09,;-4,-1.63,;-2.91,-2.72,;-3.31,-4.21,;-2.22,-5.3,;-.73,-4.9,;-.34,-3.41,;-1.42,-2.32,;-2.67,.68,;-1.33,-.09,;,.68,;,2.22,;-1.33,2.99,;-2.67,2.22,;1.33,2.99,;1.33,4.53,;2.67,5.3,;4,4.53,;5.47,5,;6.37,3.76,;5.47,2.51,;4,2.99,;2.67,2.22,)|

Structure