| Reaction Details |
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 | Report a problem with these data |
| Target | Voltage-dependent calcium channel gamma-2 subunit |
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| Ligand | BDBM292034 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biological Assays Calcium Flux Assay |
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| pH | 7.4±n/a |
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| IC50 | 25.1±n/a nM |
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| Comments | extracted |
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| Citation |  Ameriks, MK; Laforteza, BN; Savall, BM; Wade, WS; Meyer, ST; Gyuris, M 3-aryl-2H-pyrazolo[4,3-b]pyridine compounds and their use as AMPA receptor modulators US Patent US10100045 Publication Date 10/16/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Voltage-dependent calcium channel gamma-2 subunit |
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| Name: | Voltage-dependent calcium channel gamma-2 subunit |
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| Synonyms: | CACNG2 | CCG2_HUMAN | Neuronal voltage-gated calcium channel gamma-2 subunit | TARP gamma-2 | Transmembrane AMPAR regulatory protein gamma-2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 35977.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 323 |
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| Sequence: | MGLFDRGVQMLLTTVGAFAAFSLMTIAVGTDYWLYSRGVCKTKSVSENETSKKNEEVMTH
SGLWRTCCLEGNFKGLCKQIDHFPEDADYEADTAEYFLRAVRASSIFPILSVILLFMGGL
CIAASEFYKTRHNIILSAGIFFVSAGLSNIIGIIVYISANAGDPSKSDSKKNSYSYGWSF
YFGALSFIIAEMVGVLAVHMFIDRHKQLRATARATDYLQASAITRIPSYRYRYQRRSRSS
SRSTEPSHSRDASPVGIKGFNTLPSTEISMYTLSRDPLKAATTPTATYNSDRDNSFLQVH
NCIQKENKDSLHSNTANRRTTPV
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| BDBM292034 |
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| n/a |
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| Name | BDBM292034 |
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| Synonyms: | 5-(2-Isopropyl-5-(trifluoromethyl)-2H-pyrazolo[4,3-b]pyridin-3-yl)-1,3-dihydro-2H- | US10100045, Example 5 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H14F3N5O |
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| Mol. Mass. | 361.3212 |
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| SMILES | CC(C)n1nc2ccc(nc2c1-c1ccc2[nH]c(=O)[nH]c2c1)C(F)(F)F |
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| Structure | 
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