| Reaction Details |
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 | Report a problem with these data |
| Target | Voltage-dependent calcium channel gamma-2 subunit |
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| Ligand | BDBM292055 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biological Assays Calcium Flux Assay |
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| pH | 7.4±n/a |
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| IC50 | 0.032±n/a nM |
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| Comments | extracted |
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| Citation |  Ameriks, MK; Laforteza, BN; Savall, BM; Wade, WS; Meyer, ST; Gyuris, M 3-aryl-2H-pyrazolo[4,3-b]pyridine compounds and their use as AMPA receptor modulators US Patent US10100045 Publication Date 10/16/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Voltage-dependent calcium channel gamma-2 subunit |
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| Name: | Voltage-dependent calcium channel gamma-2 subunit |
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| Synonyms: | CACNG2 | CCG2_HUMAN | Neuronal voltage-gated calcium channel gamma-2 subunit | TARP gamma-2 | Transmembrane AMPAR regulatory protein gamma-2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 35977.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 323 |
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| Sequence: | MGLFDRGVQMLLTTVGAFAAFSLMTIAVGTDYWLYSRGVCKTKSVSENETSKKNEEVMTH
SGLWRTCCLEGNFKGLCKQIDHFPEDADYEADTAEYFLRAVRASSIFPILSVILLFMGGL
CIAASEFYKTRHNIILSAGIFFVSAGLSNIIGIIVYISANAGDPSKSDSKKNSYSYGWSF
YFGALSFIIAEMVGVLAVHMFIDRHKQLRATARATDYLQASAITRIPSYRYRYQRRSRSS
SRSTEPSHSRDASPVGIKGFNTLPSTEISMYTLSRDPLKAATTPTATYNSDRDNSFLQVH
NCIQKENKDSLHSNTANRRTTPV
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| BDBM292055 |
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| n/a |
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| Name | BDBM292055 |
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| Synonyms: | 7-Chloro-5-(2-cyclobutyl-5-(trifluoromethyl)-2H-pyrazolo[4,3-b]pyridin-3-yl)indolin- | US10100045, Example 26 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H14ClF3N4O |
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| Mol. Mass. | 406.789 |
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| SMILES | FC(F)(F)c1ccc2nn(C3CCC3)c(-c3cc4CC(=O)Nc4c(Cl)c3)c2n1 |
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| Structure | 
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