| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cathepsin D |
|---|
| Ligand | BDBM233139 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Fluorescence Resonance Energy Transfer (FRET)-Based Assay |
|---|
| pH | 5±n/a |
|---|
| IC50 | 1.3e+3±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Ahmed, W; Rani, M; Khan, IA; Iqbal, A; Khan, KM; Haleem, MA; Azim, MK Characterisation of hydrazides and hydrazine derivatives as novel aspartic protease inhibitors. J Enzyme Inhib Med Chem25:673-8 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cathepsin D |
|---|
| Name: | Cathepsin D |
|---|
| Synonyms: | CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 44551.72 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated. |
|---|
| Residue: | 412 |
|---|
| Sequence: | MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVP
AVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIH
HKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFG
EATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQ
PGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSL
MVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQ
AGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
|
|
|
|---|
| BDBM233139 |
|---|
| n/a |
|---|
| Name | BDBM233139 |
|---|
| Synonyms: | 2-Nitrobenzohydrazide | Mr-I-53b |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C7H7N3O3 |
|---|
| Mol. Mass. | 181.1488 |
|---|
| SMILES | NNC(=O)c1ccccc1[N+]([O-])=O |
|---|
| Structure | 
|
|---|
Search and Browse
