| Reaction Details |
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 | Report a problem with these data |
| Target | Prolyl endopeptidase FAP |
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| Ligand | BDBM50434188 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzymatic Assay |
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| pH | 8.3±n/a |
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| Temperature | 310.15±n/a K |
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| IC50 | 10.3±0.4 nM |
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| Comments | extracted |
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| Citation |  Jansen, K; De Meester, I; Heirbaut, L; Cheng, JD; Joossens, J; Augustyns, K; Van Der Veken, P FAP inhibitors US Patent US9346814 Publication Date 5/24/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Prolyl endopeptidase FAP |
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| Name: | Prolyl endopeptidase FAP |
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| Synonyms: | Fap | Fibroblast activation protein (FAP) | SEPR_MOUSE | Seprase |
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| Type: | Enzyme |
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| Mol. Mass.: | 87949.14 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | P97321 |
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| Residue: | 761 |
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| Sequence: | MKTWLKTVFGVTTLAALALVVICIVLRPSRVYKPEGNTKRALTLKDILNGTFSYKTYFPN
WISEQEYLHQSEDDNIVFYNIETRESYIILSNSTMKSVNATDYGLSPDRQFVYLESDYSK
LWRYSYTATYYIYDLQNGEFVRGYELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPP
FQITYTGRENRIFNGIPDWVYEEEMLATKYALWWSPDGKFLAYVEFNDSDIPIIAYSYYG
DGQYPRTINIPYPKAGAKNPVVRVFIVDTTYPHHVGPMEVPVPEMIASSDYYFSWLTWVS
SERVCLQWLKRVQNVSVLSICDFREDWHAWECPKNQEHVEESRTGWAGGFFVSTPAFSQD
ATSYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAIYIFRVTQDSLFYSSNEFEGYPG
RRNIYRISIGNSPPSKKCVTCHLRKERCQYYTASFSYKAKYYALVCYGPGLPISTLHDGR
TDQEIQVLEENKELENSLRNIQLPKVEIKKLKDGGLTFWYKMILPPQFDRSKKYPLLIQV
YGGPCSQSVKSVFAVNWITYLASKEGIVIALVDGRGTAFQGDKFLHAVYRKLGVYEVEDQ
LTAVRKFIEMGFIDEERIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASIY
SERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNA
QVDFQAMWYSDQNHGISSGRSQNHLYTHMTHFLKQCFSLSD
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| BDBM50434188 |
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| n/a |
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| Name | BDBM50434188 |
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| Synonyms: | CHEMBL2385281 | US9346814, Cmpd No 2 Example 3 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H16N4O2 |
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| Mol. Mass. | 308.3345 |
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| SMILES | O=C(CNC(=O)c1ccnc2ccccc12)N1CCC[C@H]1C#N |r| |
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| Structure | 
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