| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 1 |
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| Ligand | BDBM233442 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Active ERK2 (aERK) Assay |
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| IC50 | 204.1±n/a nM |
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| Citation |  Shipps, Jr., GW; Huang, X; Deng, Y; Zhu, L; Cooper, AB; Sun, B; Achab, A; Lo, S Indazole derivatives useful as ERK inhibitors US Patent US9351965 Publication Date 5/31/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 1 |
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| Name: | Mitogen-activated protein kinase 1 |
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| Synonyms: | ERT1 | Erk2 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK2) | MAP kinase 1 | MAP kinase 2 | MAP kinase ERK2 | MAPK 1 | MAPK 2 | MK01_MOUSE | Mapk | Mapk1 | Mitogen-activated protein kinase 2 | Prkm1 | p42 | p42-MAPK |
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| Type: | Protein |
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| Mol. Mass.: | 41278.65 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | P63085 |
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| Residue: | 358 |
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| Sequence: | MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQ
TYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLS
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTG
FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG
ILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRI
EVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
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| BDBM233442 |
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| n/a |
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| Name | BDBM233442 |
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| Synonyms: | US9351965, 49 | US9351965, 50 | US9351965, 51 | US9351965, 52 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H28N4O3 |
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| Mol. Mass. | 456.5362 |
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| SMILES | Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(C1)C(O)c1ccccc1 |
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| Structure | 
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