| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 7 |
|---|
| Ligand | BDBM234387 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Cell-Based Functional Assay (5-HT7) |
|---|
| IC50 | >10000±0 nM |
|---|
| Citation |  Nirogia, RV; Kambhampati, R; Daulatabad, AV; Gudla, P; Shaikh, M; Achanta, PK; Shinde, AK; Dubey, PK Design, synthesis and pharmacological evaluation of conformationally restricted N-arylsulfonyl-3-aminoalkoxy indoles as a potential 5-HT6 receptor ligands. J Enzyme Inhib Med Chem26:341-9 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 5-hydroxytryptamine receptor 7 |
|---|
| Name: | 5-hydroxytryptamine receptor 7 |
|---|
| Synonyms: | 5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-Hydroxytryptamine receptor 7 (5-HT7) | 5-hydroxytryptamine receptor 7 | 5-hydroxytryptamine receptor 7 (5-HT-7) | 5HT7R_RAT | Adrenergic Alpha | GPRFO | Htr7 | Serotonin (5-HT) receptor | Serotonin Receptor 7 |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 49852.62 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | Rat cloned 5-HT7R. |
|---|
| Residue: | 448 |
|---|
| Sequence: | MMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSWMPHLLSGFLEVTASPA
PTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSN
YLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS
IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDF
GYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVQPESVISLNGVVKLQK
EVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTS
CSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHE
ALKLAERPERSEFVLQNSDHCGKKGHDT
|
|
|
|---|
| BDBM234387 |
|---|
| n/a |
|---|
| Name | BDBM234387 |
|---|
| Synonyms: | 10-(2-N,N-Dimethylaminoethoxy)-5-Thia-4-b-azaindeno[2,1-a]indene-5,5-Dioxide (8a) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H18N2O3S |
|---|
| Mol. Mass. | 342.412 |
|---|
| SMILES | CN(C)CCOc1c2-c3ccccc3S(=O)(=O)n2c2ccccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
