Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM50334248 (1-(4-Isopropylbenzenesulfonyl)-3-(4-methylpiperazi...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd Curated by ChEMBL | Assay Description Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells by glass fiber filtration assay | Bioorg Med Chem Lett 21: 346-9 (2010) Article DOI: 10.1016/j.bmcl.2010.11.001 BindingDB Entry DOI: 10.7270/Q2P84C5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM50334254 (5-Bromo-1-(3-chlorobenzenesulfonyl)-3-(4-methylpip...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 7.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd Curated by ChEMBL | Assay Description Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells by glass fiber filtration assay | Bioorg Med Chem Lett 21: 346-9 (2010) Article DOI: 10.1016/j.bmcl.2010.11.001 BindingDB Entry DOI: 10.7270/Q2P84C5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM50334253 (3-(4-ethylpiperazin-1-yl)-1-(4-isopropylphenylsulf...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 8.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd Curated by ChEMBL | Assay Description Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells by glass fiber filtration assay | Bioorg Med Chem Lett 21: 346-9 (2010) Article DOI: 10.1016/j.bmcl.2010.11.001 BindingDB Entry DOI: 10.7270/Q2P84C5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM50334255 (5-Bromo-1-(4-fluorobenzenesulfonyl)-3-(4-methylpip...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 9.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd Curated by ChEMBL | Assay Description Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells by glass fiber filtration assay | Bioorg Med Chem Lett 21: 346-9 (2010) Article DOI: 10.1016/j.bmcl.2010.11.001 BindingDB Entry DOI: 10.7270/Q2P84C5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM50334259 (5-Bromo-1-(2-bromobenzenesulfonyl)-3-(4-methylpipe...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 10.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd Curated by ChEMBL | Assay Description Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells by glass fiber filtration assay | Bioorg Med Chem Lett 21: 346-9 (2010) Article DOI: 10.1016/j.bmcl.2010.11.001 BindingDB Entry DOI: 10.7270/Q2P84C5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM50334256 (5-Bromo-1-(4-fluorobenzenesulfonyl)-3-(4-ethylpipe...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 10.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd Curated by ChEMBL | Assay Description Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells by glass fiber filtration assay | Bioorg Med Chem Lett 21: 346-9 (2010) Article DOI: 10.1016/j.bmcl.2010.11.001 BindingDB Entry DOI: 10.7270/Q2P84C5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM50334260 (5-Chloro-1-(4-fluorobenzenesulfonyl)-3-(4-ethylpip...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 10.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd Curated by ChEMBL | Assay Description Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells by glass fiber filtration assay | Bioorg Med Chem Lett 21: 346-9 (2010) Article DOI: 10.1016/j.bmcl.2010.11.001 BindingDB Entry DOI: 10.7270/Q2P84C5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM50334250 (1-(3-chlorophenylsulfonyl)-3-(4-methylpiperazin-1-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 10.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd Curated by ChEMBL | Assay Description Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells by glass fiber filtration assay | Bioorg Med Chem Lett 21: 346-9 (2010) Article DOI: 10.1016/j.bmcl.2010.11.001 BindingDB Entry DOI: 10.7270/Q2P84C5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM50334249 (1-(4-Fluorobenzenesulfonyl)-3-(4-methylpiperazin-1...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 11.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd Curated by ChEMBL | Assay Description Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells by glass fiber filtration assay | Bioorg Med Chem Lett 21: 346-9 (2010) Article DOI: 10.1016/j.bmcl.2010.11.001 BindingDB Entry DOI: 10.7270/Q2P84C5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM50334251 (1-(2-bromophenylsulfonyl)-3-(4-methylpiperazin-1-y...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 15.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd Curated by ChEMBL | Assay Description Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells by glass fiber filtration assay | Bioorg Med Chem Lett 21: 346-9 (2010) Article DOI: 10.1016/j.bmcl.2010.11.001 BindingDB Entry DOI: 10.7270/Q2P84C5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM50334252 (3-(4-methylpiperazin-1-yl)-1-(phenylsulfonyl)-1H-i...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 15.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd Curated by ChEMBL | Assay Description Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells by glass fiber filtration assay | Bioorg Med Chem Lett 21: 346-9 (2010) Article DOI: 10.1016/j.bmcl.2010.11.001 BindingDB Entry DOI: 10.7270/Q2P84C5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM50334261 (5-Chloro-1-(2-bromobenzenesulfonyl)-3-(4-ethylpipe...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 20.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd Curated by ChEMBL | Assay Description Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells by glass fiber filtration assay | Bioorg Med Chem Lett 21: 346-9 (2010) Article DOI: 10.1016/j.bmcl.2010.11.001 BindingDB Entry DOI: 10.7270/Q2P84C5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM50334257 (5-Bromo-1-(4-isopropylbenzenesulfonyl)-3-(4-methyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 23.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd Curated by ChEMBL | Assay Description Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells by glass fiber filtration assay | Bioorg Med Chem Lett 21: 346-9 (2010) Article DOI: 10.1016/j.bmcl.2010.11.001 BindingDB Entry DOI: 10.7270/Q2P84C5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM50334266 (6-Chloro-1-(2-naphthylsulfonyl)-3-(4-ethylpiperazi...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 25.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd Curated by ChEMBL | Assay Description Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells by glass fiber filtration assay | Bioorg Med Chem Lett 21: 346-9 (2010) Article DOI: 10.1016/j.bmcl.2010.11.001 BindingDB Entry DOI: 10.7270/Q2P84C5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM50334258 (5-Bromo-1-(4-isopropylbenzenesulfonyl)-3-(4-ethylp...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 30.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd Curated by ChEMBL | Assay Description Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells by glass fiber filtration assay | Bioorg Med Chem Lett 21: 346-9 (2010) Article DOI: 10.1016/j.bmcl.2010.11.001 BindingDB Entry DOI: 10.7270/Q2P84C5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM50334267 (6-Chloro-1-(2-bromobenzenesulfonyl)-3-(4-methylpip...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 30.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd Curated by ChEMBL | Assay Description Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells by glass fiber filtration assay | Bioorg Med Chem Lett 21: 346-9 (2010) Article DOI: 10.1016/j.bmcl.2010.11.001 BindingDB Entry DOI: 10.7270/Q2P84C5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM50334262 (5-Chloro-1-(4-isopropylbenzenesulfonyl)-3-(4-ethyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 30.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd Curated by ChEMBL | Assay Description Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells by glass fiber filtration assay | Bioorg Med Chem Lett 21: 346-9 (2010) Article DOI: 10.1016/j.bmcl.2010.11.001 BindingDB Entry DOI: 10.7270/Q2P84C5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM50334264 (6-Chloro-1-(4-isopropylbenzenesulfonyl)-3-(4-methy...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 55.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd Curated by ChEMBL | Assay Description Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells by glass fiber filtration assay | Bioorg Med Chem Lett 21: 346-9 (2010) Article DOI: 10.1016/j.bmcl.2010.11.001 BindingDB Entry DOI: 10.7270/Q2P84C5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM50334265 (6-Chloro-1-(2,5-dimethoxybenzenesulfonyl)-3-(4-eth...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 63.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd Curated by ChEMBL | Assay Description Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells by glass fiber filtration assay | Bioorg Med Chem Lett 21: 346-9 (2010) Article DOI: 10.1016/j.bmcl.2010.11.001 BindingDB Entry DOI: 10.7270/Q2P84C5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM50334263 (6-Chloro-1-(4-methoxybenzenesulfonyl)-3-(4-ethylpi...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 82.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd Curated by ChEMBL | Assay Description Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells by glass fiber filtration assay | Bioorg Med Chem Lett 21: 346-9 (2010) Article DOI: 10.1016/j.bmcl.2010.11.001 BindingDB Entry DOI: 10.7270/Q2P84C5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM234385 (2-Methoxy-10-(2-N,N-Dimethylaminoethoxy)-5-Thia-4b...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 127 | -40.9 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
Suven Life Sciences Ltd | Assay Description Briefly, receptor source and radioligand used were human recombinant expressed in HEK-293 cells and [3H] LSD (6080 Ci/mmol), respectively. The ... | J Enzyme Inhib Med Chem 26: 341-9 (2011) Article DOI: 10.3109/14756366.2010.510471 BindingDB Entry DOI: 10.7270/Q2WW7GHT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM234384 (2-Chloro-10-(2-N,N-Dimethylaminoethoxy)-5-Thia-4-b...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 464 | -37.6 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
Suven Life Sciences Ltd | Assay Description Briefly, receptor source and radioligand used were human recombinant expressed in HEK-293 cells and [3H] LSD (6080 Ci/mmol), respectively. The ... | J Enzyme Inhib Med Chem 26: 341-9 (2011) Article DOI: 10.3109/14756366.2010.510471 BindingDB Entry DOI: 10.7270/Q2WW7GHT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM234386 (1-Fluoro-10-(2-N,N-Dimethylaminoethoxy)-5-Thia-4-b...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | >500 | >-37.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
Suven Life Sciences Ltd | Assay Description Briefly, receptor source and radioligand used were human recombinant expressed in HEK-293 cells and [3H] LSD (6080 Ci/mmol), respectively. The ... | J Enzyme Inhib Med Chem 26: 341-9 (2011) Article DOI: 10.3109/14756366.2010.510471 BindingDB Entry DOI: 10.7270/Q2WW7GHT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM50334249 (1-(4-Fluorobenzenesulfonyl)-3-(4-methylpiperazin-1...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 292 | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd Curated by ChEMBL | Assay Description Antagonist activity at human recombinant 5HT6 receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated cAMP accumulation by luminome... | Bioorg Med Chem Lett 21: 346-9 (2010) Article DOI: 10.1016/j.bmcl.2010.11.001 BindingDB Entry DOI: 10.7270/Q2P84C5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM50334248 (1-(4-Isopropylbenzenesulfonyl)-3-(4-methylpiperazi...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd Curated by ChEMBL | Assay Description Antagonist activity at human recombinant 5HT6 receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated cAMP accumulation by luminome... | Bioorg Med Chem Lett 21: 346-9 (2010) Article DOI: 10.1016/j.bmcl.2010.11.001 BindingDB Entry DOI: 10.7270/Q2P84C5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM50334254 (5-Bromo-1-(3-chlorobenzenesulfonyl)-3-(4-methylpip...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 322 | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd Curated by ChEMBL | Assay Description Antagonist activity at human recombinant 5HT6 receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated cAMP accumulation by luminome... | Bioorg Med Chem Lett 21: 346-9 (2010) Article DOI: 10.1016/j.bmcl.2010.11.001 BindingDB Entry DOI: 10.7270/Q2P84C5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM50334255 (5-Bromo-1-(4-fluorobenzenesulfonyl)-3-(4-methylpip...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.53E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd Curated by ChEMBL | Assay Description Antagonist activity at human recombinant 5HT6 receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated cAMP accumulation by luminome... | Bioorg Med Chem Lett 21: 346-9 (2010) Article DOI: 10.1016/j.bmcl.2010.11.001 BindingDB Entry DOI: 10.7270/Q2P84C5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM50334260 (5-Chloro-1-(4-fluorobenzenesulfonyl)-3-(4-ethylpip...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.78E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd Curated by ChEMBL | Assay Description Antagonist activity at human recombinant 5HT6 receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated cAMP accumulation by luminome... | Bioorg Med Chem Lett 21: 346-9 (2010) Article DOI: 10.1016/j.bmcl.2010.11.001 BindingDB Entry DOI: 10.7270/Q2P84C5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 3A4 (Homo sapiens (Human)) | BDBM50334255 (5-Bromo-1-(4-fluorobenzenesulfonyl)-3-(4-methylpip...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.61E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd Curated by ChEMBL | Assay Description Inhibition of human CYP3A4 | Bioorg Med Chem Lett 21: 346-9 (2010) Article DOI: 10.1016/j.bmcl.2010.11.001 BindingDB Entry DOI: 10.7270/Q2P84C5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 3A4 (Homo sapiens (Human)) | BDBM50334249 (1-(4-Fluorobenzenesulfonyl)-3-(4-methylpiperazin-1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.77E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd Curated by ChEMBL | Assay Description Inhibition of human CYP3A4 | Bioorg Med Chem Lett 21: 346-9 (2010) Article DOI: 10.1016/j.bmcl.2010.11.001 BindingDB Entry DOI: 10.7270/Q2P84C5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2D6 (Homo sapiens (Human)) | BDBM234388 (3-Chloro-10-(2-N,N-Dimethylaminoethoxy)-5-Thia-4-b...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd | Assay Description The cytochrome P450 inhibitory potential was determined using isoform-selective assays and heterologously expressed human CYP2D6 and CYP3A4. | J Enzyme Inhib Med Chem 26: 341-9 (2011) Article DOI: 10.3109/14756366.2010.510471 BindingDB Entry DOI: 10.7270/Q2WW7GHT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 3A4 (Homo sapiens (Human)) | BDBM50334248 (1-(4-Isopropylbenzenesulfonyl)-3-(4-methylpiperazi...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.54E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd Curated by ChEMBL | Assay Description Inhibition of human CYP3A4 | Bioorg Med Chem Lett 21: 346-9 (2010) Article DOI: 10.1016/j.bmcl.2010.11.001 BindingDB Entry DOI: 10.7270/Q2P84C5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2D6 (Homo sapiens (Human)) | BDBM234387 (10-(2-N,N-Dimethylaminoethoxy)-5-Thia-4-b-azainden...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 7.65E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd | Assay Description The cytochrome P450 inhibitory potential was determined using isoform-selective assays and heterologously expressed human CYP2D6 and CYP3A4. | J Enzyme Inhib Med Chem 26: 341-9 (2011) Article DOI: 10.3109/14756366.2010.510471 BindingDB Entry DOI: 10.7270/Q2WW7GHT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 3A4 (Homo sapiens (Human)) | BDBM50323062 (CHEMBL1210648 | N-(3,5-Dichloro-2-methoxyphenyl)-4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8.44E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd Curated by ChEMBL | Assay Description Inhibition of human CY3A4 | Bioorg Med Chem Lett 20: 4440-3 (2010) Article DOI: 10.1016/j.bmcl.2010.06.060 BindingDB Entry DOI: 10.7270/Q2125SV7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 3A4 (Homo sapiens (Human)) | BDBM50323061 (CHEMBL1210646 | N-(2-Bromophenyl)-4-ethyl-3-[(1-me...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 9.62E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd Curated by ChEMBL | Assay Description Inhibition of human CY3A4 | Bioorg Med Chem Lett 20: 4440-3 (2010) Article DOI: 10.1016/j.bmcl.2010.06.060 BindingDB Entry DOI: 10.7270/Q2125SV7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human)) | BDBM234388 (3-Chloro-10-(2-N,N-Dimethylaminoethoxy)-5-Thia-4-b...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd | Assay Description Muscarinic acetylcholine receptor M1 was cloned into an expression vector and transfected in CHO cells along with CRE-Luc reporter system. Isolated c... | J Enzyme Inhib Med Chem 26: 341-9 (2011) Article DOI: 10.3109/14756366.2010.510471 BindingDB Entry DOI: 10.7270/Q2WW7GHT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 7 (Rattus norvegicus (rat)) | BDBM234387 (10-(2-N,N-Dimethylaminoethoxy)-5-Thia-4-b-azainden...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd | Assay Description CHO cells were transfected with an expression vector encoding rat 5-HT7 gene and CRE-Luc reporter system. Colonies were isolated and screened with 10... | J Enzyme Inhib Med Chem 26: 341-9 (2011) Article DOI: 10.3109/14756366.2010.510471 BindingDB Entry DOI: 10.7270/Q2WW7GHT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 7 (Rattus norvegicus (rat)) | BDBM234388 (3-Chloro-10-(2-N,N-Dimethylaminoethoxy)-5-Thia-4-b...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd | Assay Description CHO cells were transfected with an expression vector encoding rat 5-HT7 gene and CRE-Luc reporter system. Colonies were isolated and screened with 10... | J Enzyme Inhib Med Chem 26: 341-9 (2011) Article DOI: 10.3109/14756366.2010.510471 BindingDB Entry DOI: 10.7270/Q2WW7GHT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human)) | BDBM234387 (10-(2-N,N-Dimethylaminoethoxy)-5-Thia-4-b-azainden...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd | Assay Description Muscarinic acetylcholine receptor M1 was cloned into an expression vector and transfected in CHO cells along with CRE-Luc reporter system. Isolated c... | J Enzyme Inhib Med Chem 26: 341-9 (2011) Article DOI: 10.3109/14756366.2010.510471 BindingDB Entry DOI: 10.7270/Q2WW7GHT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 4 (Homo sapiens (Human)) | BDBM234388 (3-Chloro-10-(2-N,N-Dimethylaminoethoxy)-5-Thia-4-b...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd | Assay Description Recombinant CHO cells were established by transfecting an expression vector encoding human 5-HT4a gene and CRE-Luc reporter system. Isolated colonies... | J Enzyme Inhib Med Chem 26: 341-9 (2011) Article DOI: 10.3109/14756366.2010.510471 BindingDB Entry DOI: 10.7270/Q2WW7GHT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 4 (Homo sapiens (Human)) | BDBM234387 (10-(2-N,N-Dimethylaminoethoxy)-5-Thia-4-b-azainden...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd | Assay Description Recombinant CHO cells were established by transfecting an expression vector encoding human 5-HT4a gene and CRE-Luc reporter system. Isolated colonies... | J Enzyme Inhib Med Chem 26: 341-9 (2011) Article DOI: 10.3109/14756366.2010.510471 BindingDB Entry DOI: 10.7270/Q2WW7GHT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2D6 (Homo sapiens (Human)) | BDBM50334249 (1-(4-Fluorobenzenesulfonyl)-3-(4-methylpiperazin-1...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.64E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd Curated by ChEMBL | Assay Description Inhibition of human CYP2D6 | Bioorg Med Chem Lett 21: 346-9 (2010) Article DOI: 10.1016/j.bmcl.2010.11.001 BindingDB Entry DOI: 10.7270/Q2P84C5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2D6 (Homo sapiens (Human)) | BDBM50334255 (5-Bromo-1-(4-fluorobenzenesulfonyl)-3-(4-methylpip...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.88E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd Curated by ChEMBL | Assay Description Inhibition of human CYP2D6 | Bioorg Med Chem Lett 21: 346-9 (2010) Article DOI: 10.1016/j.bmcl.2010.11.001 BindingDB Entry DOI: 10.7270/Q2P84C5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 3A4 (Homo sapiens (Human)) | BDBM234388 (3-Chloro-10-(2-N,N-Dimethylaminoethoxy)-5-Thia-4-b...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.71E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd | Assay Description The cytochrome P450 inhibitory potential was determined using isoform-selective assays and heterologously expressed human CYP2D6 and CYP3A4. | J Enzyme Inhib Med Chem 26: 341-9 (2011) Article DOI: 10.3109/14756366.2010.510471 BindingDB Entry DOI: 10.7270/Q2WW7GHT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2D6 (Homo sapiens (Human)) | BDBM50334248 (1-(4-Isopropylbenzenesulfonyl)-3-(4-methylpiperazi...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.92E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd Curated by ChEMBL | Assay Description Inhibition of human CYP2D6 | Bioorg Med Chem Lett 21: 346-9 (2010) Article DOI: 10.1016/j.bmcl.2010.11.001 BindingDB Entry DOI: 10.7270/Q2P84C5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2D6 (Homo sapiens (Human)) | BDBM50323062 (CHEMBL1210648 | N-(3,5-Dichloro-2-methoxyphenyl)-4...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.18E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd Curated by ChEMBL | Assay Description Inhibition of human CY2D6 | Bioorg Med Chem Lett 20: 4440-3 (2010) Article DOI: 10.1016/j.bmcl.2010.06.060 BindingDB Entry DOI: 10.7270/Q2125SV7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2D6 (Homo sapiens (Human)) | BDBM50323061 (CHEMBL1210646 | N-(2-Bromophenyl)-4-ethyl-3-[(1-me...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | >4.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd Curated by ChEMBL | Assay Description Inhibition of human CY2D6 | Bioorg Med Chem Lett 20: 4440-3 (2010) Article DOI: 10.1016/j.bmcl.2010.06.060 BindingDB Entry DOI: 10.7270/Q2125SV7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 3A4 (Homo sapiens (Human)) | BDBM234387 (10-(2-N,N-Dimethylaminoethoxy)-5-Thia-4-b-azainden...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >4.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd | Assay Description The cytochrome P450 inhibitory potential was determined using isoform-selective assays and heterologously expressed human CYP2D6 and CYP3A4. | J Enzyme Inhib Med Chem 26: 341-9 (2011) Article DOI: 10.3109/14756366.2010.510471 BindingDB Entry DOI: 10.7270/Q2WW7GHT | |||||||||||
More data for this Ligand-Target Pair |