| Reaction Details |
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 | Report a problem with these data |
| Target | Plasmepsin IV [1-448] |
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| Ligand | BDBM234520 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| pH | 4.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 18±n/a nM |
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| Comments | extracted |
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| Citation |  Chen, X; Ding, K; Meyers, MJ; Tortorella, MD; Xu, J Compositions and methods for the treatment of malaria US Patent US9353089 Publication Date 5/31/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Plasmepsin IV [1-448] |
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| Name: | Plasmepsin IV [1-448] |
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| Synonyms: | PLM4_PLAF7 | PMIV | Plasmepsin 4 (PM-IV) |
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| Type: | Enzyme |
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| Mol. Mass.: | 50925.00 |
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| Organism: | Plasmodium falciparum |
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| Description: | Q8IM16[1-448] |
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| Residue: | 448 |
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| Sequence: | MALTVKEEEFSNTLIKNASAFDRLKLGNLKNLKIQKKLQFLYLILFVLITGVFFFFLIGN
FYSHRKLYQVIKNTKHTTIGFKIDRPHDKVLSSVLKNKLSTYVKESFKFFKSGYAQKGYL
GSENDSIELDDVANLMFYGEGQIGTNKQPFMFIFDTGSANLWVPSVNCDSIGCSTKHLYD
ASASKSYEKDGTKVEISYGSGTVRGYFSKDVISLGDLSLPYKFIEVTDADDLEPIYSGSE
FDGILGLGWKDLSIGSIDPVVVELKKQNKIDNALFTFYLPVHDKHVGYLTIGGIESDFYE
GPLTYEKLNHDLYWQIDLDIHFGKYVMQKANAVVDSGTSTITAPTSFLNKFFRDMNVIKV
PFLPLYVTTCDNDDLPTLEFHSRNNKYTLEPEFYMDPLSDIDPALCMLYILPVDIDDNTF
ILGDPFMRKYFTVFDYEKESVGFAVAKN
|
|
|
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| BDBM234520 |
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| n/a |
|---|
| Name | BDBM234520 |
|---|
| Synonyms: | US9353089, 176 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H25N3O4 |
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| Mol. Mass. | 395.4516 |
|---|
| SMILES | COc1ccc(cc1)C1(NC(=N)N(C2CCOCC2)C1=O)c1ccc(OC)cc1 |
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| Structure | 
|
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