Ki Summary

Reaction Details

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Target

Cellular tumor antigen p53 [18-26]/Protein Mdm4 [2-185]

Ligand

BDBM236349

Substrate/Competitor

n/a

Meas. Tech.

Time Resolved Fluorescence Energy Transfer (TR-FRET) Assay

Temperature

298.15±n/a K

IC50

2375.7±n/a nM

Comments

extracted

Citation

Cotesta, S; Furet, P; Guagnano, V; Holzer, P; Kallen, J; Mah, R; Masuya, K; Schlapbach, A; Stutz, S; Vaupel, A Pyrrolopyrrolidinone compounds US Patent US9365576 Publication Date 6/14/2016

More Info.:

Get all data from this article, Assay Method

Cellular tumor antigen p53 [18-26]/Protein Mdm4 [2-185]

Name:

Cellular tumor antigen p53 [18-26]/Protein Mdm4 [2-185]

Synonyms:

p53-MDM4

Type:

Protein

Mol. Mass.:

n/a

Description:

n/a

Components:

This complex has 2 components.

Component 1

Name:

Cellular tumor antigen p53 [18-26]

Synonyms:

P53 | P53_HUMAN | TP53 | Tumor suppressor p53

Type:

Protein

Mol. Mass.:

1122.31

Organism:

Homo sapiens (Human)

Description:

aa 18-26

Residue:

Sequence:

TFSDLWKLL

Component 2

Name:

Protein Mdm4 [2-185]

Synonyms:

E3 ubiquitin-protein ligase Mdm4 | MDM4 | MDM4_HUMAN | MDMX | p53-binding protein Mdm4

Type:

Protein

Mol. Mass.:

20438.64

Organism:

Homo sapiens (Human)

Description:

aa 2-185

Residue:

184

Sequence:

TSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIM
VKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLA
LAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQD
ETSR

BDBM236349

n/a

Name

BDBM236349

Synonyms:

US9365576, 102

Type

Small organic molecule

Emp. Form.

C31H36ClN3O4

Mol. Mass.

550.088

SMILES

CNC(=O)c1ccc(OC)c(c1)-c1cc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1C)[C@H]1CC[C@H](O)CC1 |r,wU:35.39,wD:32.35,(8.91,-2.4,;8.14,-1.07,;6.6,-1.07,;5.83,-2.4,;5.83,.26,;6.6,1.6,;5.83,2.93,;4.29,2.93,;3.52,4.26,;4.29,5.6,;3.52,1.6,;4.29,.26,;1.98,1.6,;1.08,2.84,;-.38,2.37,;-1.85,2.84,;-2.62,4.18,;-2.75,1.6,;-1.85,.35,;-.38,.83,;1.08,.35,;1.48,-1.14,;.39,-2.22,;2.97,-1.53,;-2.25,-1.14,;-1.16,-2.22,;-1.56,-3.71,;-3.05,-4.11,;-3.44,-5.6,;-4.13,-3.02,;-3.74,-1.53,;-4.82,-.45,;-4.29,1.6,;-5.06,2.93,;-6.6,2.93,;-7.37,1.6,;-8.91,1.6,;-6.6,.26,;-5.06,.26,)|

Structure