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Targetp53-MDM2
LigandBDBM236279
Substrate/Competitorn/a
Meas. Tech.Time Resolved Fluorescence Energy Transfer (TR-FRET) Assay
Temperature298.15±n/a K
IC50 0.094±n/a nM
Commentsextracted
Citation Cotesta SFuret PGuagnano VHolzer PKallen JMah RMasuya KSchlapbach AStutz SVaupel A Pyrrolopyrrolidinone compounds US Patent  US9365576 Publication Date 6/14/2016
More Info.:Get all data from this article,  Assay Method
 
p53-MDM2
Name:p53-MDM2
Synonyms:n/a
Type:Protein
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Tumor suppressor p53
Synonyms:n/a
Type:Protein
Mol. Mass.:1122.31
Organism:Homo sapiens (Human)
Description:aa 18-26
Residue:9
Sequence:
TFSDLWKLL
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Component 2
Name:E3 ubiquitin-protein ligase Mdm2
Synonyms:n/a
Type:Protein
Mol. Mass.:21187.98
Organism:Homo sapiens (Human)
Description:aa 2-188
Residue:187
Sequence:
CNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYI
MTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTS
VSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQR
KRHKSDS
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BDBM236279
n/a
NameBDBM236279
Synonyms:US9365576, 32
TypeSmall organic molecule
Emp. Form.C32H31Cl2N3O3
Mol. Mass.576.513
SMILESCNC(=O)c1ccc(OC)c(c1)-c1cc2C(=O)N([C@H](c2n1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C |r|
Structure
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