Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetProlyl hydroxylase EGLN2
LigandBDBM240988
Substrate/Competitorn/a
Meas. Tech.HIF-PH Assay
pH7.4±n/a
IC50 240±n/a nM
Commentsextracted
Citation Ho, WZhao, HDeng, SNg, DWright, LRWu, MZhou, XArend, MPFlippin, LA 4-hydroxy-isoquinoline compounds as HIF hydroxylase inhibitors US Patent US9409892 Publication Date 8/9/2016
More Info.:Get all data from this article,  Assay Method
 
Prolyl hydroxylase EGLN2
Name:Prolyl hydroxylase EGLN2
Synonyms:EGLN2 | EGLN2_HUMAN | EIT6 | Egl nine homolog 2 | Estrogen-induced tag 6 | HIF prolyl hydroxylase | HIF-PH1 | HIF-prolyl hydroxylase 1 | HPH-3 | Hypoxia-inducible factor prolyl hydroxylase | PHD1 | Prolyl hydroxylase domain-containing protein 1 | Prolyl hydroxylase domain-containing protein 1 (PHD1)
Type:Protein
Mol. Mass.:43657.01
Organism:Homo sapiens (Human)
Description:Q96KS0
Residue:407
Sequence:
MDSPCQPQPLSQALPQLPGSSSEPLEPEPGRARMGVESYLPCPLLPSYHCPGVPSEASAG
SGTPRATATSTTASPLRDGFGGQDGGELRPLQSEGAAALVTKGCQRLAAQGARPEAPKRK
WAEDGGDAPSPSKRPWARQENQEAEREGGMSCSCSSGSGEASAGLMEEALPSAPERLALD
YIVPCMRYYGICVKDSFLGAALGGRVLAEVEALKRGGRLRDGQLVSQRAIPPRSIRGDQI
AWVEGHEPGCRSIGALMAHVDAVIRHCAGRLGSYVINGRTKAMVACYPGNGLGYVRHVDN
PHGDGRCITCIYYLNQNWDVKVHGGLLQIFPEGRPVVANIEPLFDRLLIFWSDRRNPHEV
KPAYATRYAITVWYFDAKERAAAKDKYQLASGQKGVQVPVSQPPTPT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM240988
n/a
NameBDBM240988
Synonyms:US9409892, 83
TypeSmall organic molecule
Emp. Form.C21H17N3O6
Mol. Mass.407.3762
SMILESO[C@@H](CCNC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O)C(O)=O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: