| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Transient receptor potential M8 protein |
|---|
| Ligand | BDBM241637 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Functional Assay |
|---|
| Temperature | 310.15±n/a K |
|---|
| IC50 | 0.95±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Player, MR; Calvo, R; Chen, J; Meegalla, S; Parks, DJ; Parsons, WJ; Ballentine, S; Branum, S Substituted aza-bicyclic imidazole derivatives useful as TRPM8 receptor modulators US Patent US9409915 Publication Date 8/9/2016 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Transient receptor potential M8 protein |
|---|
| Name: | Transient receptor potential M8 protein |
|---|
| Synonyms: | Cold-menthol receptor (TRPM8) | TRPM8 Receptor | Transient receptor potential M8 protein | Transient receptor potential M8 protein (TRPM8) | Transient receptor potential melastatin subfamily, type 8 (TRPM8) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 127589.43 |
|---|
| Organism: | Canis lupus familiaris (Dog) |
|---|
| Description: | Q1A7N1 |
|---|
| Residue: | 1104 |
|---|
| Sequence: | MSFEGARLSMRNRRNGTLDSTRTLYSSTSRSTDVSYSESDLVNFIQANFKKRECVFFTKD
SKATENVCKCGYAQSQHIEGTQINSNEKWNYKKHTKEFPTDAFGDIQFETLGKKGKYIRL
SCDTDAETLYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWIL
TGGTHYGLMKYIGEVVRDNTISRNSEENIVAIGIAAWGMVSNRDTLLRNCDAEGYFSAQY
IMDDFKRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTIQDSNYGGKIP
IVCFAQGGGRETLKAINTSIKSKIPCVVVEGSGQIADVIASLVEVEDVLTSSVVKEKLVR
FLPRTVSRLPEEETESWIKWLKEILESSHLLTVIKMEEAGDEIVSNAISYALYKAFSTNE
QDKDNWNGQLKLLLEWNQLDLANEEIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLEN
GLNLRKFLTNDVLTELFSNHFSTLVYRNLQIAKNSYNDALLTFVWKLVANFRRGFRKEDR
SSRDDIDVELHDVSPITRHPLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKLLKT
LAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELA
VEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGFVSFRKKPIDKH
KKILWYYVAFFTSPFVVFAWNVVFYIAFLLLFAYVLLMDFHSVPHSPELVLYALVFVLFC
DEVRQWYMNGVNYFTDLWNVMDTLGLFYFIAGIVFRLHPSNKTSLYSGRVIFCLDYIIFT
LRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEHRWRWIF
RSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLV
CIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCNRLNIPFPFVVFAY
FYMVVKKCFGCCCREKHAEPSACCFRNEDNETLAWEGVMKENYLVKINTKANDTSQEMRH
RFRQLDTKINDLKGLLKEIANKIK
|
|
|
|---|
| BDBM241637 |
|---|
| n/a |
|---|
| Name | BDBM241637 |
|---|
| Synonyms: | US9409915, 20 | US9718820, Compound 20 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H25ClF3N5O2 |
|---|
| Mol. Mass. | 507.936 |
|---|
| SMILES | COCCOc1nc(cc2nc([nH]c12)-c1c(Cl)c(nn1C)C(C)(C)C)-c1ccccc1C(F)(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
