| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase TBK1 |
|---|
| Ligand | BDBM246092 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Time-Resolved Fluorescence-based Lanthascreen Assay |
|---|
| pH | 7.5±n/a |
|---|
| IC50 | <15±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Newton, GK; Stewart, MR; Perrior, TR; Crosby, SR; Hopkins, A; Negoita-Giras, G; Jenkins, K Pyrimidine compounds useful in the treatment of diseases mediated by IKKE and/or TBK1 mechanisms US Patent US9433622 Publication Date 9/6/2016 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase TBK1 |
|---|
| Name: | Serine/threonine-protein kinase TBK1 |
|---|
| Synonyms: | NAK | NF-kappa-B-activating kinase | Protein cereblon/Serine/threonine-protein kinase TBK1 | T2K | TANK-binding kinase 1 (TBK-1) | TANK-binding kinase 1 (TBK1) | TBK1 | TBK1_HUMAN |
|---|
| Type: | protein |
|---|
| Mol. Mass.: | 83645.20 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9UHD2 |
|---|
| Residue: | 729 |
|---|
| Sequence: | MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK
KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV
GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL
HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG
KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA
ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLV
LEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITG
VVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVK
VYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQE
GTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTH
FTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETLPQ
KMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMD
GGLRNVDCL
|
|
|
|---|
| BDBM246092 |
|---|
| n/a |
|---|
| Name | BDBM246092 |
|---|
| Synonyms: | US9433622, DMX- 154 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H23N7O |
|---|
| Mol. Mass. | 401.4643 |
|---|
| SMILES | CN(C)c1ccc(nc1C#N)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1 |
|---|
| Structure | 
|
|---|
Search and Browse
