| Reaction Details |
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 | Report a problem with these data |
| Target | Sphingomyelinase C |
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| Ligand | BDBM248064 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Turbidometric Assay |
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| pH | 7.5±0 |
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| Temperature | 310.15±0 K |
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| IC50 | 3.3e+3±n/a nM |
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| Citation |  Oda, M; Imagawa, H; Kato, R; Yabiku, K; Yoshikawa, T; Takemoto, T; Takahashi, H; Yamamoto, H; Nishizawa, M; Sakurai, J; Nagahama, M Novel inhibitor of bacterial sphingomyelinase, SMY-540, developed based on three-dimensional structure analysis. J Enzyme Inhib Med Chem29:303-10 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sphingomyelinase C |
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| Name: | Sphingomyelinase C |
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| Synonyms: | PHL2_BACCE | Sphingomyelinase (SMase) | sph |
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| Type: | Enzyme |
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| Mol. Mass.: | 36871.19 |
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| Organism: | Bacillus cereus |
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| Description: | P11889 |
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| Residue: | 333 |
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| Sequence: | MKGKLLKGVLSLGVGLGALYSGTSAQAEASTNQNDTLKVMTHNVYMLSTNLYPNWGQTER
ADLIGAADYIKNQDVVILNEVFDNSASDRLLGNLKKEYPNQTAVLGRSSGSEWDKTLGNY
SSSTPEDGGVAIVSKWPIAEKIQYVFAKGCGPDNLSNKGFVYTKIKKNDRFVHVIGTHLQ
AEDSMCGKTSPASVRTNQLKEIQDFIKNKNIPNNEYVLIGGDMNVNKINAENNNDSEYAS
MFKTLNASVPSYTGHTATWDATTNSIAKYNFPDSPAEYLDYIIASKDHANPSYIENKVLQ
PKSPQWTVTSWFQKYTYNDYSDDYPVEATISMK
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| BDBM248064 |
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| n/a |
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| Name | BDBM248064 |
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| Synonyms: | SMY-610 |
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| Type | Small organic molecule |
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| Emp. Form. | C45H61N5O3 |
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| Mol. Mass. | 719.9975 |
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| SMILES | CCCCCCCCCCCCC\C=C\[C@@H](Oc1cccc(n1)-c1ccccn1)[C@H](COCc1cccc(n1)-c1ccccn1)NC(=O)CCCCC |r| |
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| Structure | 
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