| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytochrome P450 11B2, mitochondrial |
|---|
| Ligand | BDBM249242 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | G402-Based Assay |
|---|
| EC50 | 6.8±n/a nM |
|---|
| Citation |  Aebi, J; Amrein, K; Hornsperger, B; Kuhn, B; Maerki, HP; Mayweg, AV; Tan, X Dihydroquinoline-2-one derivatives US Patent US9458135 Publication Date 10/4/2016 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cytochrome P450 11B2, mitochondrial |
|---|
| Name: | Cytochrome P450 11B2, mitochondrial |
|---|
| Synonyms: | Aldosterone Synthase (CYP11B2) | Aldosterone synthase | Aldosterone-synthesizing enzyme | C11B2_HUMAN | CYP11B2 | CYPXIB2 | Cytochrome P450 11B2 | Cytochrome P450 11B2 (CYP11B2) | Cytochrome P450 11B2, mitochondrial | P-450Aldo | P-450C18 | Steroid 18-hydroxylase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 57582.15 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P19099 |
|---|
| Residue: | 503 |
|---|
| Sequence: | MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
IKMVYSFILRPGTSPLLTFRAIN
|
|
|
|---|
| BDBM249242 |
|---|
| n/a |
|---|
| Name | BDBM249242 |
|---|
| Synonyms: | US9458135, 30 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H19ClN4O2 |
|---|
| Mol. Mass. | 406.865 |
|---|
| SMILES | CN1C(=O)CCc2cc(ccc12)-c1cncc(CC(=O)Nc2cccc(Cl)n2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
