Ki Summary

Reaction Details

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Target

Isoform 2 of Nuclear receptor ROR-gamma (RORgT)

Ligand

BDBM256386

Substrate/Competitor

n/a

Meas. Tech.

TR-FRET Assay

7±n/a

Temperature

277.15±n/a K

IC50

50±n/a nM

Comments

extracted

Citation

Barr, KJ; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Andresen, BM; Anthony, NJ; Lapointe, BT; Sciammetta, N 3-cyclohexenyl and cyclohexyl substituted indole and indazole compounds as RORgammaT inhibitors and uses thereof US Patent US9487490 Publication Date 11/8/2016

More Info.:

Get all data from this article, Assay Method

Isoform 2 of Nuclear receptor ROR-gamma (RORgT)

Name:

Isoform 2 of Nuclear receptor ROR-gamma (RORgT)

Synonyms:

Type:

Protein

Mol. Mass.:

55831.73

Organism:

Homo sapiens (Human)

Description:

P51449-2

Residue:

497

Sequence:

MRTQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRN
RCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGA
QGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCH
LEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPE
APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCA
HHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGK
YGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQ
LQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPL
YKELFSTETESPVGLSK

BDBM256386

n/a

Name

BDBM256386

Synonyms:

US9487490, 9A

Type

Small organic molecule

Emp. Form.

C23H19ClF4N2O3

Mol. Mass.

482.855

SMILES

C[C@@]1(CC[C@@H](CC1)c1nn(C(=O)c2c(Cl)cccc2C(F)(F)F)c2cccc(F)c12)C(O)=O |r,wU:4.7,1.0,wD:1.33,(-2.14,8.14,;-2.41,6.62,;-3.44,5.48,;-2.96,4.01,;-1.45,3.69,;-.42,4.84,;-.9,6.3,;-.98,2.23,;-1.88,.98,;-.98,-.27,;-1.45,-1.73,;-.42,-2.87,;-2.96,-2.05,;-3.99,-.91,;-3.51,.56,;-5.5,-1.23,;-5.97,-2.69,;-4.94,-3.84,;-3.44,-3.51,;-2.41,-4.66,;-2.8,-6.15,;-1.32,-5.75,;-.87,-4.66,;.49,.21,;1.82,-.56,;3.15,.21,;3.15,1.75,;1.82,2.52,;1.82,4.06,;.49,1.75,;-3.51,7.69,;-4.99,7.27,;-3.14,9.18,)|

Structure