Reaction Details | |||
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Target | Poly [ADP-ribose] polymerase tankyrase-2 [946-1162] | ||
Ligand | BDBM259569 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Biochemical Assay | ||
IC50 | 0.626±n/a nM | ||
Citation | Bregman, H; Buchanan, JL; Chakka, N; Dimauro, EF; Gunaydin, H; Guzman-Perez, A; Hua, Z; Huang, X Quinazolinone compounds and derivatives thereof US Patent US9505749 Publication Date 11/29/2016 | ||
More Info.: | Get all data from this article, Assay Method | ||
Poly [ADP-ribose] polymerase tankyrase-2 [946-1162] | |||
Name: | Poly [ADP-ribose] polymerase tankyrase-2 [946-1162] | ||
Synonyms: | PARP5B | TANK2 | TNKL | TNKS2 | TNKS2_HUMAN | Tankyrase-2 | ||
Type: | Enzyme | ||
Mol. Mass.: | 24581.05 | ||
Organism: | Homo sapiens (Human) | ||
Description: | aa 946-1162 | ||
Residue: | 217 | ||
Sequence: |
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BDBM259569 | |||
n/a | |||
Name | BDBM259569 | ||
Synonyms: | US9505749, 80 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H24N4O4 | ||
Mol. Mass. | 432.4718 | ||
SMILES | O=C(CCc1nc2ccccc2c(=O)[nH]1)N[C@H]1CC[C@@H](CC1)n1c2ccccc2oc1=O |r,wU:19.24,wD:16.17,(2.71,5.99,;2.71,4.45,;1.38,3.68,;.04,4.45,;-1.29,3.68,;-2.62,4.45,;-3.96,3.68,;-5.29,4.45,;-6.62,3.68,;-6.62,2.14,;-5.29,1.37,;-3.96,2.14,;-2.62,1.37,;-2.62,-.17,;-1.29,2.14,;4.04,3.68,;4.04,2.14,;2.71,1.37,;2.71,-.17,;4.04,-.94,;5.38,-.17,;5.38,1.37,;4.04,-2.48,;2.8,-3.38,;1.29,-3.06,;.26,-4.21,;.74,-5.67,;2.24,-5.99,;3.27,-4.85,;4.81,-4.85,;5.29,-3.38,;6.62,-2.61,)| | ||
Structure |