Ki Summary

Reaction Details

Report a problem with these data

Target

Poly [ADP-ribose] polymerase tankyrase-2 [946-1162]

Ligand

BDBM259588

Substrate/Competitor

n/a

Meas. Tech.

Biochemical Assay

IC50

0.362±n/a nM

Citation

Bregman, H; Buchanan, JL; Chakka, N; Dimauro, EF; Gunaydin, H; Guzman-Perez, A; Hua, Z; Huang, X Quinazolinone compounds and derivatives thereof US Patent US9505749 Publication Date 11/29/2016

More Info.:

Get all data from this article, Assay Method

Poly [ADP-ribose] polymerase tankyrase-2 [946-1162]

Name:

Poly [ADP-ribose] polymerase tankyrase-2 [946-1162]

Synonyms:

Type:

Enzyme

Mol. Mass.:

24581.05

Organism:

Homo sapiens (Human)

Description:

aa 946-1162

Residue:

217

Sequence:

LNTSGSGTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKL
WERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENS
SKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSV
TGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPEG

BDBM259588

n/a

Name

BDBM259588

Synonyms:

US9505749, 100

Type

Small organic molecule

Emp. Form.

C23H24FN3O3S

Mol. Mass.

441.518

SMILES

Fc1ccc(O[C@H]2CC[C@@H](CC2)NC(=O)CCSc2nc3ccccc3c(=O)[nH]2)cc1 |r,wU:9.12,wD:6.5,(6.67,-5.78,;6.67,-4.23,;5.33,-3.47,;5.33,-1.93,;6.67,-1.15,;6.67,.38,;5.33,1.15,;5.33,2.69,;4,3.47,;2.67,2.69,;2.67,1.15,;4,.38,;1.33,3.47,;1.33,5,;2.67,5.78,;,5.78,;-1.33,5,;-2.67,5.78,;-4,5,;-4,3.47,;-5.33,2.69,;-5.33,1.15,;-6.67,.38,;-8,1.15,;-8,2.69,;-6.67,3.47,;-6.67,5,;-8,5.78,;-5.33,5.78,;8,-1.93,;8,-3.47,)|

Structure